摘要目的 分析评估同一RapidPlan计划自动优化模块在选用不同放疗设备时产生的剂量学差异.方法 采用30例宫颈癌患者以加速器A为治疗设备,对其计划进行再次优化,并建立一RapidPlan计划优化模型.用另外12例宫颈癌患者作为测试样本,分别在以加速器A、加速器B、加速器C、加速器D建模治疗计划系统上行RapidPlan模块自动计划设计,分析评估模块产生的各治疗计划间剂量学差异并行配对样本t检验.结果 B、C、D组与A组的PTV50和PTV45剂量指标Dmean、HI、CI及直肠和膀胱V50、V40、V30均不同,尤其是与D组比较,P值均<0.05.结论 基于解剖特性和先验知识的RapidPlan自动计划优化模块,在采用不同放疗设备进行剂量优化时会带来剂量学上的一些差异,在临床使用中需谨慎对待.

abstractsObjective To evaluate the dosimetric differences of one RapidPlan Model on different Radiotherapy devices.Methods A RapidPlan Model was built based on 30 reoptimization IMRT plans of cervical cancer patients on type"A" LA.Dosimetric differences of automatic optimized IMRT plans using this model on 4 different type LAs,named respectively"A","B","C" and"D",were compared with 12 test cervical cancer cases.These four LAs were well commissioned in the treatment planning system (TPS).Student t test was applied for statistical analysis on dosimetric differences.Results Dosimetric differences between A vs.B,C and D were observed on Dmean,HI,CI of PTV50 and PTV45,as well as on V50,V40,V30 of rectum and bladder.Significant dosimetric differences were observed between A and D (P<0.05).Conclusions Automatic planning with RapidPlan model may result in dosimetric differences on different Radiotherapy devices.These differences should be aware of with caution in its clinical application.