摘要小动物放疗模型的相关理论及其应用,对于放射生物学和临床肿瘤放疗学的研究与发展至关重要.而综合考虑普适性与成本效应等因素,研究人员常运用小鼠模型来研究肿瘤与正常组织的放射生物学机制.近年来,基于不同图像引导的小动物立体放疗设备也取得了巨大发展,它们已能较好模拟人体放疗流程.本文着重介绍了基于不同图像方式(如CBCT与MRI)引导的小动物放疗系统,其次对小动物荧光成像技术进行理解学习,总结对比了不同生物发光与荧光成像设备在小动物成像系统中的应用,最后对未来小动物放疗设备优化方向提出展望.

abstractsThe theory and application of small animal radiotherapy models is critical for the research and development of radiobiology and clinical radiotherapy.Considering universality and cost effects,mouse models are widely used to explore the radiobiological mechanisms of cancerous and normal tissues.In recent years,there has been tremendous progress in image-guided stereotactic radiotherapy equipment for small animals,which could simulate the human radiotherapy process.This article introduces stereotactic radiotherapy systems for small animals guided by different imaging modalities,such as cone-beam computed tomography and magnetic resonance imaging,and then reviews small animal fluorescence imaging technology and summarizes the application of different bioluminescence and fluorescence imaging equipment in small animal imaging systems.Finally,we put forward the prospect of optimization direction of radiotherapy equipment for small animals in future.