摘要近年来,肠道菌群及其代谢物与肿瘤发生、炎性肠病、肠道放射损伤的关系越来越受到研究者重视.源于核事故调查、临床研究、动物模型探索等多种证据证实,肠道菌群及其代谢物可作为评估肠道放射损伤暴露水平与严重程度的生物标记物.本文综述肠道菌群及其代谢物与肠道受照剂量、放射损伤的关系,为评估肠道放射损伤风险提供理论参考.

abstractsRecently,the relationship between intestinal flora and its metabolites and tumorigenesis,inflammatory bowel diseasesas well as radiation-induced intestinal injury has captivated widespread attention from researchers.Accumulated evidence derived from nuclear accident investigation,animal model experiment and clinical research has proven the role of intestinal flora and its metabolites as the biomarkers to evaluate the radiation dose and severity of radiation-induced intestinal injury.This article reviews the relationship between intestinal flora and its metabolites and radiation-induced intestinal injury,aiming to provide theoretical reference for assessing the risk of radiation-induced intestinal injury.