摘要放射性肺炎(RP)作为胸部放疗最常见的不良反应,通常发生在放疗开始后3个月内。RP不仅直接导致患者肺功能和生活质量的下降,而且限制了处方剂量的给定和放疗计划的实施,影响放疗疗效,严重时甚至导致患者死亡。目前有大量研究致力于探索预测RP的因素,本综述就其中与临床相关的预测因素进行分类阐述,包括剂量学参数、外周血细胞及细胞因子及肺功能参数等,旨在提供有价值的预测指标,以便临床应用,减少RP的发生。
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abstractsRadiation pneumonitis (RP) is the most common adverse event of thoracic radiotherapy, which primarily occurs within the 3 months after the beginning of radiotherapy. RP can not only negatively affect the pulmonary function and quality of life of patients, but also limit the prescribed dose and the implementation of radiotherapy plan, lower the radiotherapy efficacy and even lead to death. Currently, multiple studies have been conducted to explore the predictive factors of RP. In this article, clinical predictive factors including dosimetric parameters, peripheral blood cells along with cytokines and pulmonary function parameters were classified and illustrated, aiming to provide valuable predictive indicators for clinical use and reduce the incidence of RP.
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