摘要目的 探讨肝硬化门脉高压症继发食管胃底静脉曲张、脾功能亢进患者行手助腹腔镜(hand-assisted laparoscopic surgery,HALS)脾切除、贲门周围血管离断术与开腹脾切除、贲门周围血管离断术(open splenectomy,OS)的肝功能变化及临床疗效.方法 回顾分析2002年1月至2008年5月施行脾切除责门周围血管离断术治疗肝硬化门静脉高压症94例,其中手助腹腔镜手术(HALS组)38例,开腹手术(OS组)56例.术前按Child法进行肝功能分级,对比分析两组手术时间、术中失血、术后并发症发生率、肝功能损害和病死率.结果 手助腹腔镜组与开腹组两组手术用时差异无显著性(P＞0.05);术中平均出血量、并发症发生率分别为5.6%和10.8%,差异有统计学意义(P＜0.05);两组术后ALT比较差异无统计学意义,ALB比较差异有统计学意义(P＜0.05),AST第5天比较差异有统计学意义(P＜0.05);HALS组ALT、AST术后均较术前升高,但只有AST升高有统计学意义(P＜0.05);OS组ALT、AST术后均比术前显著升高,差异均有统计学意义(P＜0.05);两组ALB术后均比术前降低,OS组差异均有统计学意义(P＜0.05),HALS组仅第1、3天差异有统计学意义(P＜0.05).结论 手助腹腔镜脾切除、贲门周围血管离断术对肠道和肝功能影响较开腹组小,术后并发症少,是安全可行的.

abstractsObjective To investigate the changes in liver function and the efficacy of either hand-assisted laparoscopic surgery (HALS) or open splenectomy (OS) in combination with pericardial devascularization in the treatment of portal hypertension. Methods The clinical data of 94 patients who received splenectomy combined with pericardial devascularization to treat portal hypertension due to cirrhosis from Jan 2002 to May 2008 were analyzed retrospectively. 56 patients received OS and 38patients HALS. The operating time, intraoperative blood loss, postoperative complications, liver dysfunction and mortality were analyzed according to the Child's grading. Results There was no difference in the operating time between HALS and OS (P＞0. 05). The intraoperative blood loss and postoperative complications were 5.6% and 10.8%, respectively (P＜0. 05). There was no significant difference in the serum ALT between HALS and OS, but there was a significant difference in the ALB (P＜0. 05). The AST also had a significant difference on postoperative day 5 (P＜0. 05). The serum ALT and AST were elevated after HALS, but there was a significant difference only for AST (P＜0.05). The serum ALT and AST in OS were significantly higher after than before operation (P＜0. 05). The serum ALB in OS was significantly lower after operation (P＜0.05), but it was significantly lower only on postoperative days 1 and 3 (P＜0.05) in HALS. Conclusions Compared with OS, HALS combined with pericardial devascularization caused less damage to the intestinal tract and the liver function. It is a feasible and safe operation and it had fewer postoperative complications.