摘要目的 探讨肝移植术后新发恶性肿瘤的患病率及预防方法.方法 回顾性分析我院2000年5月至2010年12月640例肝移植术患者的病历及随访资料,总结肝移植术后新发恶性肿瘤的患病率、肿瘤类型,分析肝移植术后新发恶性肿瘤的发病特点.结果 我院肝移植术后新发恶性肿瘤患病率为1.56％,低于欧美,与国内数据相似.肿瘤类型分别为伯基特淋巴瘤(肝移植术后淋巴组织增殖性疾病)、肺母细胞瘤、急性髓性白血病(AML)、膀胱癌、胃癌、乙状结肠癌、直肠癌、肾透明细胞癌各1例以及肝癌2例.结论 肝移植术前原发疾病类型、免疫抑制强度、年龄以及不同人种肿瘤发病特点等的不同,可能是我中心肝移植术后新发恶性肿瘤患病率低于欧美的原因.早期发现和治疗,才能改善新发肿瘤患者的预后.

abstractsObjectives To determine the incidence of de novo neoplasms after liver transplantation and methods of prevention.Methods The clinical data of 605 patients after liver transplantation carried out from May 2000 to December 2010 in our centre were analysed.The patient's gender,age,primary disease and the clinical characteristics of post-transplantation de novo neoplasms were analysed.Results The incidence of de novo post-transplantation neoplasms was 1.80％.There was one case of post-transplantation lymphoproliferative disorders (PTLD),one case of pulmonary blastoma,one case of acute myelogenous leukemia,one case of bladder tumor,one case of gastric carcinoma,one case of sigmoid colon carcinoma,one case of carcinoma of rectum,one case of renal clear cell carcinoma and two cases of hepatocellular carcinoma.Conclusion There was a low incidence of de novo posttransplantation neoplasm in our centre than that reported in the West,probably because of variations in patient selection,immunosuppression regimens used,patients' age and different patient ethnic groups.Early diagnosis and treatment of de novo neplasm helped to improve prognosis.