摘要目的 探讨手术联合阿苯达唑脂质体治疗晚期泡型肝包虫病的效果及临床价值.方法 回顾性分析2002年1月至2013年1 1月71例晚期泡型肝包虫病患者临床资料.根据手术方式的不同及是否联合阿苯达唑脂质体治疗将患者分为四组进行分析比较.结果 术后随访时间最短5个月,最长44个月,单纯减体手术治疗组病死率为82.3％ (14/17);减体手术+阿苯达唑治疗组病死率为52.3％(11/21);单纯根治手术治疗组病死率为28.5％ (4/14);根治手术+阿苯达唑治疗组病死率为21.1％(4/19).根治术+阿苯达唑治疗组病死率与根治手术组及减体手术+阿苯达唑治疗组比较差异有统计学意义(P＜0.05);单纯根治手术组病死率与减体手术+阿苯达唑治疗组比较差异无统计学差异(P＞0.05);单纯减体手术治疗组病死率与减体手术+阿苯达唑治疗组以及单纯根治手术组与根治术+阿苯达唑治疗组比较差异有统计学意义(P＜0.05).结论 手术联合阿苯达唑脂质体治疗晚期泡型肝包虫病,可降低或减少患者术后复发的可能,提高患者生活质量和延长生命.

abstractsObjective To investigate the outcomes of surgery combined with albendazole liposomes in the treatment of advanced hepatic alveolar echinococcosis.Methods This is a retrospective study on 71 patients with advanced hepatic alveolar echinococcosis treated from January 2002 to November 2013.The patients were divided into 4 groups according to the surgical methods and whether surgery was combined with albendazole liposomes.Results On follow-up from 5 ～ 44 months,the mortality rates for the volume-reduction surgery group was 82.3％,the volume-reduction surgery + albendazole group 52.3％,the radical operation group 28.5％,and the radical operation + albendazole group 21.1％.The mortality rate of the radical operation + albendazole group,when compared with the radical operation group and the volume-reduction surgery + albendazole group was significantly different (P ＜ 0.05).The mortality rate of the radical operation group,when compared with the volume-reduction surgery + albendazole group showed no significant difference (P ＞ 0.05).The mortality rate of the volume-reduction surgery group,when compared with the volume-reduction surgery + albendazole group,the radical operation group,and the radical operation + albendazole group was significantly different (P ＜ 0.05).Conclusions The treatment of radical operation combined with albendazole liposomes for advanced hepatic alveolar echinococcosis reduced recurrence,improved quality of life and prolonged survival.It is a feasible method to treat these patients.