摘要胃肠胰神经内分泌肿瘤(GEP-NETs)是一类起源于消化系统神经内分泌细胞的肿瘤.近年来其发病率逐渐上升.GEP-NETs临床表现多样,相关分子机制也较为复杂.尽管目前已有越来越多的针对GEP-NETs的基础研究,然而其形成及转移机制仍未完全阐明.本文汇总了近期有关GEP-NETs基础研究的最新进展,阐述了其新发现的肿瘤形成分子机制,涉及受体及其通路、基因突变及表观遗传学改变等多个方面.

abstractsGastroenteropancreatic neuroencrine tumors (GEP-NETs) originate from the neuroendocrine cells of the digestive system.Over the past few years,the incidence has increased gradually.The clinical manifestations are diverse,and the related molecular mechanism is also more complex.Although there are more and more basic researches for GEP-NETs,the mechanism for carcinogenesis and metastasis has not been fully elucidated.This paper summarizes the latest progress on the development of GEP-NETs,and elaborates the new findings on tumor molecular mechanisms,mainly including the related receptors and its signaling pathways,gene mutations and epigenetic changes.