摘要胰腺癌是恶性程度最高的肿瘤之一,发病率在我国呈逐年上升的趋势.针对胰腺癌的治疗已进入多学科综合治疗时代.为选择最佳治疗方式,实现尽可能改善患者预后的目的,寻找更精准的胰腺癌临床分期方法势在必行.胰腺癌主要的临床分期方法,除了传统的TNM分期,还有肿瘤组织病理学分期(G)、术后切缘分期(M).此外,还需考虑是否有淋巴管侵犯(L)、血管侵犯(V)、神经侵犯(P).这些分期方法联合起来又被美国国立综合癌症网(NCCN)制定的指南推荐为一种新的分期方案,即综合(GTNMLVP)分期.除此之外还有边界可切除状态分期、胰腺外科规范化分期、基因学分期等.本文就胰腺癌精准分期及其临床价值进行综述.

abstractsPancreatic carcinoma remains one of the most challenging malignant tumor with an increasing morbidity in China.The significance of multidisciplinary and comprehensive treatment of pancreatic cancer has been recognized in recent years.Moreover,several novel clinical staging standards of pancreatic cancer have emerged to help optimize the treatment strategies and improve patients' prognosis in precise treatment era.Currently,in addition to the traditional TNM stage,usage of histologic grade (G),resection marginstatus (M),lymphatic invasion status (L),vascular invasion status (V),perineurial invasion status (P) and combination of these stages recommended by NCCN guideline as GTNMLVP stage have emerged.Other novel staging standards include respectability status,standardized pancreatic surgery classification,genetics classification,etc.This review summarized the characteristics and clinical significance of these novel established methods for pancreatic cancer precise staging.