摘要损伤相关分子模式(DAMPs)分子是细胞损伤或激活后释放的具有免疫调节活性的多种细胞内分子,可通过模式识别受体诱导自身免疫或免疫耐受.目前已发现的DAMPs分子包括胞外组蛋白、高迁移率族蛋白-1、染色体脱氧核糖核酸、白细胞介素18、白细胞介素32、尿酸、线粒体转录因子等.DAMPs分子的发现及其作用机制的阐明,将有助于了解肝衰竭的病理生理过程,并为肝衰竭的诊断和防治提供新的思路.现就DAMPs的概念及其在肝衰竭发生和发展过程中的作用机制进行总结.

abstractsDamage-associated molecular patterns (DAMPs) are a series of intracellular molecules with immunoregulatory activity which are released by the damaged or activated cells and can induce autoimmunity or immune tolerance via pattern recognition receptors.At present,the DAMPs which have been discovered include extracellular histone,high-mobility group box-1,chromosomal deoxyribonucleic acid,interleukin-18,interleukin-32,uric acid,and mitochondrial transcription factors.The discovery of DAMPs and clarification of their mechanisms of action help to know the pathophysiological process of liver failure and provide new thoughts for the diagnosis,prevention,and treatment of liver failure.This article briefly summarizes the concept of DAMPs and their mechanisms of action in the development and progression of liver failure.