摘要肝性脑病(HE)是由严重肝病或门体分流引起的,以代谢紊乱为基础、中枢神经系统功能失调为主要表现的综合征.氨在HE的发生、发展过程中具有重要作用.幽门螺杆菌(H.pylori)具有尿素酶活性,可增加胃液氨浓度.然而H.pylori与血氨、HE的关系,以及根除H.pylori对HE的治疗作用尚无定论,研究结果充满矛盾.临床工作中是否需要对HE患者检测H.pylori并进行根除治疗,该文就此进行综述.

abstractsHepatic encephalopathy (HE) is caused by severe liver disease or portal shunt.Metabolic disorders and central nervous system dysfunctions are the main symptoms of this syndrome.Ammonia is considered to play a central role in the pathogenesis of HE.Helicobacter pylori (H.pylori) have been suggested as a possible source of ammonia production because of its high urease content.However,the relationship between H.pylori and blood ammonia and HE,as well as the therapeutic effect of H.pylori eradication on HE,is inconclusive,and the results are full of contradictions.The aim of this review is to summarize current knowledge on the association of H.pylori with HE and to address the question of whether H.pylori eradication may be beneficial in the management of HE.