摘要目的 探讨肿瘤坏死因子受体超家族1B (TNFRSF1B)基因多态性与丙型肝炎病毒(HCV)感染结局的相关性.方法 纳入1 645例无HCV感染者,545例HCV清除者,783例HCV慢性化者,采用TaqMan探针法对rs1061622 (T＞ G)和rs1061624 (G＞ A)两个单核苷酸多态性位点(SNP)进行基因分型,并构建单倍型,评估其与HCV感染结局的相关性. 结果 经logistic回归分析均两个SNPs与HCV感染的易感性和慢性化无相关性(P值均＞0.05).单倍型分析显示,携带TA单倍型可增加HCV感染的易感性[调整后比值比(OR)=1.15,95％可信区间(CI):1.01～ 1.30,P=0.038)1,携带TA和GG单倍型均有利于HCV感染慢性化(调整后OR=1.28,95％ CI:1.08 ～ 1.53,P=0.006;OR=1.31,95％ CI:1.03 ～ 1.66,P=0.026). 结论 TNFRSF1B基因rs1061622和rs1061624的共同效应可增加HCV感染和慢性化的风险.

abstractsObjective To investigate the tumor necrosis factor receptor superfamily 1B gene (TNFRSF1B) polymorphism in relation to the outcomes of hepatitis C virus (HCV) infection.Methods One thousand six hundred and forty-five cases without HCV infection,545 cases with HCV clearance,and 783 cases with chronic HCV infection were enrolled.TaqMan probe method was used to investigate genotype rs1061622 (T ＞ G) and rs1061624 (G ＞ A).Two single nucleotide polymorphisms (SNPs) sites were genotyped and haplotypes were constructed to evaluate their relation with the outcome of HCV infection.Results Logistic regression analysis showed that there was no relation to the two SNPs with HCV infection susceptibility and chronicity (P ＞ 0.05).Haplotype analysis showed that carrier TA had an increased susceptibility to HCV infection [adjusted odds ratio (OR) =1.15,95％ confidence interval (CI):1.01 to 1.30,P =0.038)].Carrier TA and GG haplotypes were conducive to chronic HCV infection (adjusted OR =1.28,95％ CI:1.08 to 1.53,P =0.006;OR =1.31,95％ CI:1.03 to 1.66,P =0.026).Conclusion The combinational effects of rsl061622 and rs1061624 in TNFRSF1B gene may increase the risk ofHCV chronicity and infection.