换一批
换一批结核合并丙型肝炎病毒感染同时治疗的药物选择
Drug selection for simultaneous treatment of tuberculosis combined with hepatitis C virus infection
摘要临床上经常遇到结核病（TB）合并丙型肝炎病毒（HCV）感染者需要同时治疗。当抗HCV和抗TB药物联用时需要考虑药物-药物之间的相互作用（DDIs）、抗TB药物诱导的肝毒性，以及肝脏疾病状态。现重点讨论常用抗TB和抗HCV药物的代谢机制和联用药物的选择，为TB合并HCV感染患者提供合理的用药选择。
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abstractsClinically, patients with tuberculosis (TB) combined with hepatitis C virus (HCV) infection often require simultaneous treatment. Consequently, when anti-HCV and TB drugs are used in combination drug-drug interactions (DDIs), anti-TB drug-induced hepatotoxicity, and liver disease states need to be considered. This paper focuses on discussing the metabolic mechanisms of commonly used anti-TB and HCV drugs and the selection options of combined drugs, so as to provide rational drug use for TB patients combined with HCV infection.
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关键词
结核病丙型肝炎病毒药物代谢药物交叉反应抗病毒治疗药物性肝损伤肝硬化TuberculosisHepatitis C virusDrug metabolismDrug-drug interactionsAntiviral treatment regimenDrug-induced liver injuryLiver cirrhosis
栏目名称
综述
DOI
10.3760/cma.j.cn501113-20201224-00675
发布时间
2025-02-25
基金项目
云南省中青年学术和技术后备人才项目
the 18
th Yunnan Province Cultivation Project of the Skilled Personnel
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