摘要目的 实时监测和观察晕船人员食管下端pH值的变化以及药物的干预作用,为运动病的防治提供理论依据.方法 健康志愿者36例,均为男性.采用瑞典Medtronic Synectics公司生产的DigitrapperMKⅢ型便携式pH监测仪,动态监测航行前、航行期间及口服法莫替丁后食管下端pH各参数的变化.结果 (1)航行中食管下端pH三项监测指标较航行前差异均有统计学意义(P＜0.05);(2)口服法莫替丁后,除pH ＜4的反流次数与航行中相比差异无统计学意义(P＞0.05)外,pH ＜4的总时间百分数及反流持续＞5 min次数与航行中相比差异均有统计学意义(P＜0.05).结论 晕船人员在较大风浪中航行时,食管下端酸反流较航行前明显增加,口服法莫替丁可明显抑制航行时的食管酸反流.食管下端pH监测可用于晕船情况下防治食管酸反流的药物筛选及疗效评价.

abstractsObjective To monitor changes of pH in the lower part of esophagus in the ship crew with motion sickness and effects of drug intervention,so as to provide theoretical evidence for the prevention and treatment of motion sickness.Methods Thirty-six male healthy volunteers were involved in the study.Portable pH monitoring system (Digitrapper MK Ⅲ,Medtronic Synectics Corporation,Sweden) was used to dynamically monitor pH changes before and during deployment,and also to observe pH changes in the lower part of esophagus in the subjects following oral administration of famotidine.Results (1) Statistical significance could all be seen in the 3 pH indexes in the lower part of esophagus monitored during deployment among the ship crew with motion sickness (P ＜ 0.05).(2) Following oral administration of famotidine,there was statistical significance in the percentage of total time (pH ＜ 4) and the frequency of sustained reflux (＞ 5 min),as compared with those during deployment,but the frequency of sustained reflux (pH ＜ 4) was an exception,when it was compared with that during deployment (P ＞ 0.05).Conclusions During deployment,in rough sea conditions,acid reflux in the lower part of esophagus among the ship crew with seasickness was obviously severer than that before deployment.Oral administration of famotidine could obviously inhibit acid reflux among the ship crew with seasickness during deployment.Detection of pH level in the lower part of esophagus could be used in the screening of drugs for the prevention and treatment of acid reflux and the evaluation of therapeutic effects as well.