摘要目的:评价吗啉硝唑联合高压氧对Wagner 2～4级糖尿病足创面感染生物标志物水平的影响及临床疗效。方法:回顾性分析2021年1月至2023年11月复旦大学附属金山医院收治的89例Wagner 2～4级糖尿病足患者的临床资料。按照治疗方法的不同，将患者分为观察组（46例）和对照组（43例）。对照组单纯采用吗啉硝唑治疗，观察组采用吗啉硝唑联合高压氧治疗，连续治疗3周后，比较2组治疗前后以及2组间的炎症指标、厌氧菌清除率、临床总有效率以及不良反应发生率。结果:治疗前，2组间炎症指标［全血白细胞计数（WBC）、血清C反应蛋白（CRP）、降钙素原（PCT）、白细胞介素-6（IL-6）］差异均无统计学意义（均 P>0.05）；治疗后，2组炎症指标均低于治疗前（均 P<0.05），且观察组水平均低于对照组（均 P<0.05）。治疗后，观察组厌氧菌清除率为95.65%，对照组为74.42%，差异有统计学意义（ P<0.05）；观察组临床总有效率为97.83%，对照组为81.40%，差异有统计学意义（ P<0.05）；观察组不良反应发生率为8.70%，对照组为6.98%，差异无统计学意义（ P>0.05）。 结论:吗啉硝唑联合高压氧治疗Wagner 2～4级糖尿病足的效果确切，比单用吗林硝唑药物治疗能更有效地控制糖尿病足创面感染，促进糖尿病足的愈合。

abstractsObjective:To evaluate the effect of morinidazole combined with hyperbaric oxygen therapy on the levels of infection biomarkers and clinical efficacy of Wagner grades 2–4 diabetic foot ulcer infection.Methods:The clinical data of 89 selected patients with Wagner grades 2–4 diabetic foot ulcer ， hospitalized in our hospital from January 2021 to November 2023 ， were retrospectively analyzed. The patients were divided into observation group（46 cases ） and control group（43 cases ） based on different treatment methods. The control group was treated with morinidazole sodium chloride injection only ， while the observation group received hyperbaric oxygen therapy additionally. Both groups were treated continuously for 3 weeks ， and the levels of inflammatory markers ， anaerobic bacteria clearance rate ， clinical total effect rate ， and incidence of adverse reactions were compared before and after treatment ， as well as between the two groups. Results:There were no statistically significant difference in inflammatory markers［white blood cell count（WBC） ， serum C-reactive protein（CRP） ， procalcitonin（PCT），and interleukin-6（IL-6）］between the two groups before treatment（ P>0.05 ）. After 3 weeks of treatment ， the levels of inflammatory markers in both groups were significantly decreased than those before treatment（ P<0.05 ）， and the levels in the observation group were significantly lower than those in the control group（ P<0.05 ）. The anaerobic bacteria clearance rate after treatment was 95.65% in the observation group and 74.42% in the control group ， with a statistically significant difference（ P<0.05 ）； the clinical total effective rate after treatment was 97.83% in the observation group and 81.40% in the control group ， with a statistically significant difference（ P<0.05 ）； the incidence of adverse reactions was 8.70% in the observation group and 6.98% in the control group ， with no statistically significant difference（ P>0.05 ）. Conclusion:Morinidazole combined with hyperbaric oxygen therapy is effective in the treatment of Wagner grades 2–4 diabetic foot ulcers ， which can more effectively control the infection of diabetic foot ulcers and improve the healing of diabetic foot ， compared with using morinidazole alone.