摘要目的 观察服用莫达非尼对雷达作业人员夜班作业能力的影响. 方法将值夜班(0:00～8:00)的20名男性雷达作业人员按随机数字表随机分为莫达非尼组和安慰剂组(每组n=10).于夜间2:00口服莫达非尼200 mg或安慰剂.在夜班前、后分别进行计算机模拟雷达信号及跟踪目标识别绩效、临界闪光融合频率(CFF)和数字划消成绩测试,夜班工作中对心电、心率等指标进行动态监测. 结果安慰剂组夜班后的CFF值(29.64±1.46)较夜班前(30.94±1.88)明显下降(t=5.87,P<0.01);莫达非尼组夜班后的CFF值(31.65±1.49)和数字划消总数(100.50±12.57)分别较夜班前(CFF值为29.85±2.65,数字划消总数为88.50±12.70)明显升高(t=5.94、14.54,P<0.05).与安慰剂组比较,莫达非尼组夜班后的数字划消总数和CFF值明显提高(t=2.70、2.73,P<0.05);莫达非尼组的心率、标化低频功率、低频与高频功率的比值增高,低频功率、高频功率、标化高频功率和总功率降低,相邻正常R-R间期差值的均方根值和极低频功率明显降低(t=2.41、2.37,P<0.05). 结论夜班作业时口服常规单剂量莫达非尼具有明显提高雷达操作能力和抗疲劳的效果.

abstractsObjective To investigate the effects of taking modafinil on performance of servicemen in radar troops during night shift. Methods Twenty servicemen in radar troops were served as subjects. They were randomly divided into modafinil and placebo groups(n= 10). 200 mg of modafinil or placebo was orally administered at 2:00 in night shift(0:00～8:00) respectively. Before and after night shift the following parameters were measured: performance of computer simulated radar signal pursuing tasks,critical flicker fusion frequency(CFF), performance of crossing out test. The electrocardiogram and heart rate were continually recorded during the night shift. Results CFF values of post-duty (29.64±1.46) were significantly decreased when compared with those of pre-duty (30.94±1.88) in placebo group(t=5.87, P<0.01). In modafinil group, CFF values (31.65±1.49) and total amount of crossing out (100.50±12.57) of post-duty were significantly higher than those of pre-duty (t= 5.94, 14. 54, P<0. 05). Compared with the placebo group, total amount of crossing out and CFF values of post-duty in modafinil group were significantly increased (t = 2.70, 2.73, P 0. 05). Compared with the placebo group, heart rate, low frequency normalized and low frequency power/high frequency power were increased; but LF, HF, high frequency normalized and total power were decreased, especially root mean squared successive difference and very low frequency power were remarkably decreased in modafinil group (t = 2.41, 2.37, P < 0.05) during the night shift. Conclusions Modafinil orally taking at routine dose could significantly enhance the performance and anti-fatigue abilities of servicemen in radar troops during night shift.