摘要目的:综述飞行空间定向障碍发生机制的研究进展并对其进行展望。资料来源与选择:国内外该领域相关文献。资料引用:国内外公开出版发表的相关书籍文献41篇。资料综合:飞行空间定向障碍发生率高、对飞行安全威胁大，且与神经中枢密切相关，对飞行空间定向障碍发生机制及神经中枢机制的研究尤为必要。由于生理状态下空间认知的研究进展缓慢，所以飞行空间定向障碍机制的早期研究大都停留在宏观层面。随着近年来神经科学和脑科学的飞速发展，揭示了海马、内嗅皮层及边缘系统在生理状态下构建空间认知地图的部分机制，为开展飞行空间定向障碍中枢机制的研究提供了条件和基础。结论:研究飞行空间定向障碍发生机制，可以为其预警和预防提供新的有针对性的干预靶点，对有效降低飞行空间定向障碍的发生率以及导致的事故率具有重要的军事意义。

abstractsObjective:To review the research progress of the mechanism of flight spatial disorientation and prospect it.Literature resource and selection:Domestic and foreign literatures published in this field.Literature quotation:Forty-one articles published at home and abroad were cited.Literature synthesis:The incidence of flight spatial disorientation is high and it greatly threats to flight safety. It is closely related to the nerve center. Therefore, it is particularly necessary to study the mechanism of flight spatial disorientation and its nerve center mechanism. Due to the slow progress in the research of spatial cognition in physiological states, most of the early studies on the mechanism of spatial disorientation in flight remained at the macro level. With the rapid development of neuroscience and brain science in recent years, part of the mechanism of constructing spatial cognitive map in the hippocampus, entorhinal cortex and limbic system under physiological state has been revealed, which provides conditions and basis for the research of the central mechanism of flight spatial disorientation.Conclusions:Research on the mechanism of flight spatial disorientation can provide new intervention targets for early warning and prevention, and it has critical military significance to effectively reduce the incidence of flight spatial disorientation and related accident rate.