摘要目的 通过炎症兔模型99Tcm-环丙沙星与99Tcm-非特异性人多克隆免疫球蛋白(HIgG)显像的比较,评估99Tcm-环丙沙星的特异性.方法 建立4组兔模型.组1为无菌性炎症模型,组2为细菌性炎症模型,组3为右后肢无菌性炎症、左后肢细菌性炎症模型,组4为空白对照组.各组饲养7 d后行99Tcm-环丙沙星显像,2 d后再行99Tcm-HIgG显像,并比较2次显像结果.结果 静脉注射99Tcm-环丙沙星1 h炎症部位就显影,延迟至3～4 h,图像更清晰.组1无菌性炎症兔模型99Tcm-环丙沙星显像明性,99Tcm-HIgG阳性.组2细菌性炎症兔模型99Tcm-环丙沙星和99Tcm-HIgG显像均为阳性.组399Tcm-环丙沙星显像在左后肢细菌性炎症中有异常放射性分布,右后肢非细菌性炎症中未见明显显影;99Tcm-HIgG显像在左后肢细菌性炎症和右后肢非细菌性炎症中均有放射性浓聚.组4则2种显像均为阴性.结论 99Tcm-环丙沙星能特异定位细菌性炎症灶,在非细菌性炎症部位无浓聚.最佳显像时间为给药后3 h.

abstractsObjective 99Tcm-ciprofloxacin(Infecton)and 99Tcm-HIgG are both radiopharmaceuticals for inflammation and infectious disease imaging.It was reported that99Tcm-ciprofloxacin (Infecton)Was able to distinguish inflammation from infection.while 99Tcm-HIgG was a nonspecific agent.The study Was designed to compare the in vivo characteristics between 99Tcm-ciprofloxacin(Infecton)and 99Tcm-HIgG in rabbit model of inflammation.Methods Eight rabbits were grouped as inflammation model(the first group).infection model(the second group),concomitant inflammation and infection model(the third group),and control(the fourth group)groups.A total of 185 MBq(0.5 m1)99Tcm-ciprofloxacin(Infecton)Was administered intravenously to each rabbit.a serious dynamic images were acquired till 24 h post-injection.Repeated examination with99Tcm-HIgG was carried out 2 d later.Resuits 99Tcm-ciprofloxacin(Infecton)scan was negative in the inflammation models and controls.and was positive in the infection models.In the third group99Tcmciprofloxacin(Infecton)showed infection focus in the left thigh but negative uptake at inflammation focus in the right thigh.99Tcm-HIgG scan were positive in all models.The optimal image time for99Tcm-ciprofloxacin(Infecton)was 3 h after administration.but positive image could still be observed 24 h later.Conclusion 99Tcm-ciprofloxacin(Infecton)appears to specifically accumulate in the infective lesion.