摘要目的 利用99Tcm-TRODAT-1 SPECT脑显像观察抽动秽语综合征(TS)患者纹状体DAT的结合能力,探讨纹状体99Tcm-TRODAT-1的摄取率与年龄、病程及抽动严重性之间的关系.方法 选取未经治疗的TS患者18例:男14例,女4例,年龄(24±10)岁;性别、年龄匹配的健康对照者8名.所有受检者按体质量静脉注射99Tcm-TRODAT-1 11.1～14.8 MBq/kg,2.5 h后行脑SPECT显像.分别在双侧纹状体及进一步划分的尾状核和壳核勾画感兴趣区,以小脑为本底,计算纹状体/小脑放射性比值,该值反映纹状体对99Tcm-TRODAT-1的摄取率.采用独立样本t检验将TS患者与对照组的99Tcm-TRODAT-1摄取率进行比较;采用Pearson相关分析将患者摄取率与年龄、病程、抽动严重性等做进一步相关分析.结果 TS患者双侧纹状体对99Tcm-TRODAT-1的摄取率明显高于对照组(2.17±0.23与1.87±0.24,t=2.957,P＜0.05),且分布对称;纹状体摄取率与患者年龄(r=-0.320,P＞0.05)、抽动严重性(r=0.345,P＞0.05)无关,但与病程呈负相关(r=-0.483,P＜0.05),病程越短,摄取率越高.结论 未经治疗的TS患者DAT功能活性较对照组明显增强;DAT活性增高程度与病程呈负相关.99Tcm-TRODAT-1 SPECT脑显像可作为初诊TS患者确诊的客观依据.

abstractsObjective To observe dopamine transporter (DAT) binding capacity using 99Tcm-TRODAT-1 in drug-naive patients with Tourette's syndrome (TS) on SPECT imaging, and explore possible correlations between 99Tcm-TRODAT-1 uptake ratio and TS patient's age, disease duration, and tic severity.Methods Eighteen drug-naive TS patients, male 14, female 4, as well as 8 age- and gender-matched healthy subjects were recruited. Brain SPECT imaging was performed 2. 5 h after intravenous injection of 11.1 - 14.8 MBq/kg 99Tcm-TRODAT-1. ROI was drawn on the striatum including its sub-regions of caudate and putamen, with cerebellum as the background. Striatum/cerebellum ratio was calculated. Comparisons of the ratios between TS patients and controls were carried out by independent-sample t-test. Pearson correlation analysis was performed between DAT uptake ratios of striatum and patients' age, disease duration, tic severity. Results Compared with the control, higher symmetrically striatum uptake of 99Tcm-TRODAT-1 in TS patients was observed (2.17±0.23 vs 1.87±0.24, t =2.957, P＜0.05). Age (r= -0.320, P＞0.05)and tic severity(r = 0. 345, P ＞ 0.05) scores were not significantly correlated with specific uptake ratios measured in the striatum. But there was significant negative correlation between disease duration and the specific uptake ratios (r = - 0. 483, P ＜ 0. 05). Conclusions 99 Tcm-TRODAT-1 SPECT imaging may play an adjuvant role for initial evaluation of untreated TS.