心脏交感神经正电子显像剂的研究进展

Development of PET agent for cardiac sympathetic nervous system

二维码有效期 120s

摘要在许多心脏疾病中,心脏交感神经的变化在出现临床症状之前已经发生.PET/CT显像能够高灵敏地反映心脏交感神经的变化.该文介绍了11C和18F标记的几种心脏交感神经显像剂的研究新进展.其中11C-羟基麻黄素(11C-HED)和18F-6-氟多巴胺(18F-FDA)为研究最深入的2种显像剂,而11C-N-甲基多巴胺(11C-MDA)和18F-N-[3-溴-4-(3-18F-氟代丙氧基)-苄基]-胍(18F-LMI1195)为新研发的有良好临床应有潜质的显像剂.

abstractsMany cardiac sympathetic changes occur before clinical symptoms being found in heart disease.PET/CT imaging can sensitively detect abnormal cardiac sympathetic nerve function.The recent development of several 11 C and 18F labeled cardiac sympathetic imaging agents is reviewed in this paper.11C-meta-hydroxyephedrine (11 C-HED) and 6-18F-fluorodopamine (18F-FDA) have been comprehensively studied already.N-11C-CH3-dopamine (11C-MDA) and N-(3-bromo-4-(3-18F-fluoropropoxy)-benzyl)-guanidine (18F-LMI1195) are novel imaging agents with potential for clinical application.

作者何玉林 ^[1] 张锦明 ^[2] 学术成果认领

作者单位内蒙古医科大学附属医院核医学科,呼和浩特,010050 ^[1] 解放军总医院核医学科, 北京,100853 ^[2]

关键词放射性示踪剂正电子发射断层显像术交感神经系统心脏发展趋势 Radioactive tracers Positron-emission tomography Sympathetic nervous system Heart Trends

主题词心脏(Heart)研究(Research)电子(Electrons)放射性示踪剂(Radioactive Tracers)正电子发射断层显像术(Positron-Emission Tomography)

栏目名称综述

DOI 10.3760/cma.j.issn.2095-2848.2017.04.012

发布时间 2017-07-31

基金项目

国家自然科学基金 内蒙古自治区卫生和计划生育委员会医疗卫生科研计划项目(201302069)National Natural Science Foundation of China Medical and Health Research Project of Inner Mongolia Autonomous Region's Health and Family Planning Committee