摘要目的 采用18F-硝基咪唑丙醇(FMISO)PET/CT显像评估甘氨双唑钠(CMNa)对食管癌的放射增敏作用.方法 前瞻性选取2016年12月至2017年12月本院胸外科确诊的食管癌患者60例,按完全随机分组法分成对照组[男21例、女9例,年龄(56.6±10.0)岁]和试验组[男20例、女10例,年龄(59.3±9.0)岁];对照组采取单纯放疗,试验组在常规放疗时给予CMNa治疗.每组患者治疗前1周及治疗结束后1周均行18F-FMISO PET/CT显像,对显像结果行视觉分析和半定量分析,测得病灶最大标准摄取值(SUVmax).计算肿瘤与肌肉的摄取比值(T/M)、乏氧体积(HV)等参数.采用配对t检验、两样本t检验和x2检验分析数据.结果 对照组治疗前后T/M为3.92±0.57和1.66±0.35,HV为(1.84±0.31)和(1.04±0_15)mm3;试验组治疗前后T/M为4.01±0.68和1.27±0.11,HV为(2.01±0.22)和(0.90±0.09)mm3;放疗后2组患者原发灶T/M和HV均明显小于放疗前(t值:12.15-24.43,均P<0.05),且试验组T/M和HV下降幅度明显大于对照组[?T/M:2.77±0.60和2.25±0.49,?HV:(1.12±0.18)和(0.81±0.26)mm3;t值:3.00和1.80,均P<0.05].3个月后随访,试验组食管癌的局部控制率高于对照组[80.0%(24/30)和53.3%(16/30);x2=4.80,P<0.05].结论 CMNa对食管癌具有放射增敏作用,18F-FMISO PET/CT显像可对其进行评估.

abstractsObjective To investigate the feasibility of sodium glycididazole(CMNa)on the radio-sensitization of esophageal cancer(EC)by 18F-fluoromisonidazole(FMISO)PET/CT.Methods A total of 60 patients with EC from December 2016 to December 2017 were enrolled prospectively and were divided into control group(n = 30;21 males,9 females;age:(56.6±10.0)years)and experimental group(n=30;20 males,10 females;age:(59.3±9.0)years)using completely randomized grouping design.Patients in the control group received radiotherapy alone,and those in the experimental group were treated with conventional radiotherapy and CMNa.All patients underwent 18F-FMISO PET/CT imaging 1 week before and after radiotherapy.The imaging results were visually and semi-quantitatively analyzed.The maximum standardized uptake value(SUVmax),tumor/muscle ratio(T/M),and hypoxia volume(HV)were calculated.Paired t test,two-sample t test and/x2 test were used to analyze the data.Results T/M and HV in the control group before and after radiotherapy were 3.92±0.57 vs 1.66±0.35,(1.84±0.31)vs(1.04±0.15)mm3,respectively;T/M and HV in the experimental group before and after radiotherapy were 4.01±0.68 vs 1.27±0.11,(2.01±0.22)vs(0.90±0.09)mm3,respectively.The primary tumor T/M,HV after radiotherapy in 2 groups were significantly lower than those before radiotherapy(t values:12.15-24.43,all P<0.05)and the amplitudes of T/M and HV in the experimental group were significantly higher than those in the control group(?T/M:2.77±0.60vs 2.25±0.49,?HV:(1.12±0.18)vs(0.81±0.26)mm3;t values:3.00 and 1.80,both P<0.05).Meanwhile,the local control rate of EC after 3 months in the experimental group was higher than that in the control group(80.0%(24/30)vs 53.3%(16/30);x2=4.80,P<0.05).Conclusion CMNa has the radiosensitizing effect on EC and the 18F-FMISO PET/CT can evaluate the radiosensitization effect.