摘要目的 探讨鼻咽癌原发灶病理类型、分化程度、T分期及肿瘤体积与18 F-氟硝基咪唑(FMISO)PET/CT显像最大标准摄取值(SUVmax)的相关性.方法 回顾性收集2012年至2015年间行头颈部18 F-FMISO PET/CT显像的41例鼻咽癌患者(男31例,年龄18～74岁;女10例,年龄35～67岁)的资料,分析鼻咽癌组织病理类型、分化程度、T分期、肿瘤体积等参数与原发灶SUVmax之间的关系.采用Mann-Whitney u检验、近似t检验和Spearman相关分析进行统计学处理.结果 非角化性癌和鳞状细胞癌原发灶的SUVmax差异无统计学意义(u=183.5,P>0.05),分化型与未分化的鼻咽癌原发灶SUVmax差异也无统计学意义(t'=-1.23,P>0.05);T1～T2期与T3～T4期鼻咽癌原发灶SUVmax分别为1.52±0.43、2.05±0.85,差异有统计学意义(t'=-2.60,P<0.05).SUVmax与肿瘤体积有一定相关性(rs=0.488,P<0.05).结论 鼻咽癌原发灶乏氧程度与T分期及肿瘤体积有关,综合分析有助于评估氧负荷及判断预后.

abstractsObjective To explore the relationship between the maximum standardized uptake value ( SUVmax ) of 18 F-fluoromisonidazole ( FMISO) PET/CT and the pathological classification, differentiation, T stage and primary tumor volume of nasopharyngeal carcinoma ( NPC) . Methods A retrospective analysis was performed on 41 patients with NPC (31 males, age 18-74 years;10 females, age 35-67 years) who underwent head and neck 18 F-FMISO PET/CT from 2012 to 2015. The relationship between the clinicopath-ological parameters (pathological classification, differentiation, T stage, tumor volume) of primary lesion and SUVmax were analyzed. Mann-Whitney u test, approximate t test and Spearman correlation were used for data analysis. Results There was no significant difference in SUVmax between non-keratinizing carcinoma and squamous cell carcinoma ( u=183.5, P>0.05) , nor between the differentiated carcinoma and undiffer-entiated carcinoma( t'=-1.23, P>0.05) . SUVmax of T1-T2 primary tumor was significantly lower than that of T3-T4 tumor (1.52±0.43 vs 2.05±0.85; t'=-2.60, P<0.05), and SUVmax was correlated with primary tumor volume ( rs=0.488, P<0.05) . Conclusions The hypoxic degree is related with T stage and primary tumor volume in NPC. The combination analysis of T stage and tumor size will contribute to the assessment of oxygen level and prognosis of primary NPC.