摘要神经内分泌肿瘤(NETs)有特定亚类的生长抑素受体(SSTRs)过度表达,177Lu-1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸-D-苯丙氨酸1-酪氨酸3-苏氨酸8-奥曲肽(DOTATATE)为生长抑素类似物,可与SSTRs特异性结合,在NETs早期诊断、临床分期、指导治疗、复发和转移病灶的探查中具有重要意义,在肿瘤放射性核素靶向治疗方面作用更为突出.多肽受体放射性核素治疗(PRRT)不良反应相对轻微,对于延长患者无进展生存期、改善症状以及提高生活质量具有重要意义.

abstractsSome subtypes of somatostatin receptors ( SSTRs) are overexpressed in neuroendocrine tumors (NETs). 177Lu-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-D-Phel-Tyr3-Thr8-octreoti-de ( DOTATATE) is a somatostatin analogue that can be combined with somatostatin receptor specifically, which plays an important role not only in early diagnosis, clinical staging, treatment guiding, recurrence de-tection and metastasis of NETs, but also in the targeted radionuclide therapy of tumors. The side effect of peptide receptor radionuclide therapy is relatively mild, which is of great clinical significance for prolonging patients' survival, improving symptoms and the quality of life.