摘要目的 评价代谢综合征(MS)及其组分与甲状腺结节之间的相关性.方法 回顾性分析2009年6月至2010年6月于大连医科大学附属第二医院体检中心体检的10 357例18岁以上个体的人体学指标、空腹血糖、血脂、血尿酸及丙氨酸转氨酶以及甲状腺彩超检查的结果.结果 甲状腺结节的患病率为46.96%,MS患病率为23.6%,两病共患病率为11.6%.MS组甲状腺结节的发病率较非MS组明显升高(75.9%vs 38.0%,P＜0.05).多因素Logistic回归分析甲状腺结节的发生与MS、体质指数、空腹血糖独立相关(β=0.78,OR=4.167,P＜0.05;β=1.22,OR=3.876,P＜0.05;β=0.62,OR=2.359,P＜0.05).结论 MS个体甲状腺结节患病率显著增高.多元回归分析表明MS各组分中体质指数与空腹血糖是甲状腺结节发生的独立预测因子.甲状腺是代谢综合征另一个受累靶器官.

abstractsObjective To evaluate the relationship of metabolic syndrome (MS) and MS components with thyroid nodule. Methods A total of 10 357 subjects ( age ＞ 18 years old) who received physical checkup at the Second Affiliated Hospital of Dalian Medical University between June 2009 and June 2010 were enrolled in this retrospective study. Anthropometric parameter, fasting plasma glucose (FPG),serum lipid profile, blood uric acid, alanine aminotransferase and thyroid ultrasonography were measured. Results The prevalence of thyroid nodule,MS,and thyroid nodule + MS was 46. 96% ,23. 6%,and 11.6%, respectively. The prevalence of thyroid nodule was significantly higher in MS patients than in non MS patients ( 75.9% vs 38. 0%, P ＜ 0. 05 ). Multifactor logistic analysis showed that MS, body mass index (BMI) and FBG (β vales were 0. 78,1.22,and 0. 62,respectively; odds ratios were 4. 167,3. 876,and 2. 359, respectively; all P ＜ 0. 05 ) were independently correlated with the development of thyroid nodule. Conclusions Significantly increased prevalence of thyroid nodule could be found in MS patients. BMI and FBG may be independent risk factors of thyroid nodule.