摘要目的:分析正常体重人群中基于定量CT（QCT）技术测量内脏脂肪面积与脂肪肝的相关性。方法:本研究为横断面研究。选取2021年1至12月于河南省人民医院健康管理学科行胸部CT联合QCT检查的1 305名体检者为研究对象，QCT测量腰2锥体中心层面体质成分，包括皮下脂肪面积（SFA）、内脏脂肪面积（VFA）及肝脏脂肪含量（LFC），收集血脂、血糖等代谢指标。采用 t检验、 χ2检验分析LFC和脂肪肝检出率与年龄、性别相关性。根据VFA<100 cm 2、100 cm 2≤VFA<150 cm 2、VFA≥150 cm 2将体检者分为3组，采用单因素方差分析和 χ2检验进行组间比较。以多元线性回归分析VFA及代谢指标与LFC的相关性。 结果:1 305例体检者中男634例，女671例。正常体重指数（BMI）人群脂肪肝检出率65.67%，男性和女性检出率分别为72.71%、59.02%（ χ2=27.12， P<0.001），LFC及脂肪肝检出率随年龄增加而增长（均 P<0.05）。随着VFA增高，年龄、BMI、SFA、LFC、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇、空腹血糖（FBG）、丙氨酸转氨酶（ALT）、血尿酸及脂肪肝患病率递增（均 P<0.05），低密度脂蛋白胆固醇递减（ P<0.001）。多元线性回归分析显示，校正年龄因素后，无论男、女性，LFC与VFA、BMI、ALT均呈独立正相关（男性 β=0.206、0.145、0.174，女性 β=0.194、0.150、0.184；均 P<0.05）；FBG与男性独立正相关（ β=0.134， P<0.001）；与女性独立相关的指标有TC、TG、血尿酸（ β=-0.121、0.145、0.141，均 P<0.05）。 结论:在BMI正常健康体检人群中，基于QCT技术测量VFA与脂肪肝关系密切。

abstractsObjective:To analyze the association between visceral fat area (VFA) and fatty liver based on quantitative CT (QCT) in people receiving health examination with normal body mass index (BMI).Methods:A cross-sectional study. A total of 1 305 physical examiners who underwent chest CT and QCT examination in the Department of Health Management of Henan Provincial People′s Hospital from January to December 2021 were retrospectively selected as subjects. The physical components at the central level of the lumbar two cone were measured with QCT, including subcutaneous fat area (SFA), VFA and liver fat content (LFC). And the metabolic indexes, such as blood lipids and blood glucose, were collected. The t-test and χ2 test were used to analyze the correlation between the detection rate of fatty live and LFCr and age and gender. According to level of VFA (<100 cm 2, 100-150 cm 2 and≥150 cm 2), the subjects were divided into three groups, and one-way ANOVA and χ2 test were used in comparison between groups. Multiple linear regression was used to analyze the correlation between VFA and metabolic indexes and LFC. Results:Of the 1 305 subjects, there were 634 males and 671 females. The detection rate of fatty liver in normal BMI population was 65.67%, and it was 72.71% and 59.02% respectively in men and women ( χ2=27.12, P<0.001), and the detection rate of fatty liver and LFC increased with age (both P<0.05). With the increase of VFA, the age, BMI, SFA, LFC, total cholesterol (TC), triacylglycerol (TG), low-density lipoprotein cholesterol (LDL-C), fasting blood glucose (FBG), alanine aminotransferase (ALT), blood uric acid and prevalence of fatty liver increased (all P<0.05), and the low-density lipoprotein cholesterol (HDL-C) decreased ( P<0.001). Multiple linear regression analysis showed that after adjustment for age factors, regardless of male or female, LFC was independently positively related with VFA, BMI, and ALT (male β=0.206, 0.145, 0.174, female β=0.194, 0.150, 0.184; all P<0.05). FBG was positively correlated with male independently ( β=0.134; P<0.001). The indicators related to female independently were TC, TG, and blood uric acid ( β=-0.121, 0.145, 0.141, all P<0.05) Conclusion:In the population receiving health examination with normal BMI, the VFA measured by QCT technique is closely related to fatty liver.