摘要目的 探讨女性抑郁患者的双侧海马及其各部形态体积变化的特点.方法 采用3.0 T磁共振,分别测量女性抑郁患者(30例,抑郁组)及对照组(30名)的海马及其各部体积和层数.结果 (1)抑郁组左侧海马头平均层面积(121±33)mm2,小于对照组的(148±32)mm2;层数(14.9±3.2)层,多于对照组的(12.3±3.1)层;P均<0.01;抑郁组左右侧尾部层数[(5.9±2.6)层,(6.4±1.8)层]少于对照组[(7.7±2.5)层,(7.8±2.3)层],P<0.05.(2)抑郁组左右侧海马体积[(3164±218)mm3,(3202±202)mm3]、于对照组[(3324±334)mm3,(3338±301)mm3],P<0.05,海马左右侧尾体积[(384±120)mm3,(414±101)mm3]亦小于对照组[(498±134)mm3,(501±121)mm3],P<0.01.结论 左侧海马头部形态改变和两侧海马尾体积缩小及其形态改变可能是女性抑郁患者的特征之一.

abstractsObjective To study the characteristics of the changes in hippocampcal volumes in female patients with major depressive disorder (MDD).Methods The volumes and layers of the entire hippocampus and its subunits were measured in 30 normal females and 30 MDD female patients with 3.0T magnetic resonance.Results (1) The average areas of each layer of the left hippocampal head in patients was less than that in the normal(P<0.01), while the layer number of the head was more than that in the normal(P<0.01).The layer number of bilateral hippocampal tail in patients were less than the normal (P=0.01).(2)The volume of bilateral hippocampus in females with MDD were less than control (P<0.05 ).The volume of hippocampcal tails were obviously less in patients than the normal (P<0.01 ).Conclusion It is suggested that the morphological changes in left hippocampal head and volume loss in hippocampal tail be in the female patients with MDD.