摘要创伤后应激障碍（posttraumatic stress disorder，PTSD）是一种与创伤经历有关的精神障碍，核心症状包括闯入或重复体验、回避、负性认知和情绪的改变以及过度警觉。认知加工疗法（cognitive processing therapy，CPT）通过阻止回避、释放真实情感、识别和挑战“阻滞点”等核心治疗步骤，可能通过改变小脑、中央执行网络和默认网络等相关脑区的功能连接改善PTSD症状。目前国外已有大量实证研究验证了CPT的疗效，但国内却尚未见推广该疗法。因此，本文拟总结CPT在不同人群的临床应用及其可能的治疗机制，以期为CPT的本土化提供循证医学证据。

abstractsPosttraumatic stress disorder (PTSD) is a kind of mental disorder associated with traumatic experiences. The core symptoms of PTSD include intrusions, avoidance of trauma reminders, negative alterations in cognitions and mood and alterations in arousal. Cognitive processing therapy (CPT) may reduce PTSD symptoms by changing the connectivity of cerebellum, central executive network, and default mode network through the core therapeutic steps of preventing avoidance, releasing true emotion, and recognizing and challenging "stuck points". At present, a large number of empirical studies abroad have certified the significant efficacy of CPT, but it has not been widely promoted in China. Therefore, this article intends to summarize the clinical application of CPT in different populations and its possible therapeutic mechanism, in order to provide evidence-based medical evidence for the localization and clinical application in China.