摘要抑郁症（major depressive disorder，MDD）是致残率最高的疾病之一，临床上约有1/3的MDD患者在连续服用抗抑郁药多个疗程后没有显著改善，最终转变为难治性抑郁症（treatment-resistant depression，TRD）。TRD是一种更为严重、复杂的疾病亚型，临床治疗具有挑战性。强迫症（obsessive-compulsive disorder，OCD）是以反复出现强迫观念和（或）强迫行为为基本特征的一类精神障碍，与其他精神疾病的高共病率已被确定为OCD的标志性特征，其中以MDD共病OCD最为常见，且症状更为严重，自杀发生概率更高。磁抽搐治疗（magnetic seizure therapy，MST）是一种新型非侵入性神经调控技术，可安全有效治疗TRD，且认知损伤更小。本文报道了1例TRD共病OCD的患者在经100 Hz快速MST治疗后症状显著改善的案例。作为一种新的治疗选择，未来仍需要更多的大型临床研究进一步探索。

abstractsMajor depressive disorder (MDD) is one of the most disabling illnesses, and approximately one-third of patients with MDD fail to show significant improvement after multiple courses of antidepressants, eventually progressing to treatment-resistant depression (TRD), a more severe and complex subtype that is difficult to treat. Obsessive-compulsive disorder (OCD) is a type of mental disorder characterized by repetitive obsessions and/or compulsive behaviors, and the high rate of comorbidity with other psychiatric disorders has been identified as a hallmark feature of OCD. In particular, OCD frequently co-occurs with MDD, and when these two conditions overlap, the resulting comorbidity is characterized by more severe symptoms and an increased risk of suicide. Magnetic seizure therapy (MST) is a novel, non-invasive neuromodulation technique that is safe and effective in the treatment of TRD with less cognitive impairment. This paper describes a case of significant symptom improvement following 100 Hz accelerated MST treatment in a patient with comorbid TRD and OCD. As a novel treatment option, MST requires further large-scale clinical trials to explore in the future.