摘要精神分裂症是一种全球范围内常见的、重型的、复杂的精神疾病。遗传因素约占精神分裂症病因的80%，但其仍缺乏客观诊断标志物。本文报告2例女性同卵双胞胎患精神分裂症，22q11.2和4p15.3之间发生平衡易位。我们结合文献对患者染色体平衡易位区域与精神疾病发病相关性进行分析和讨论，从而促进精神科医生从新视角去思考精神分裂症的诊断。

abstractsSchizophrenia is a common, severe, and complex psychiatric disorder worldwide. Genetic factors account for around 80% of the etiology of schizophrenia, yet objective diagnostic biomarkers remain lacking. This article reports two cases of female monozygotic twins diagnosed with schizophrenia, exhibiting a balanced translocation between 22q11.2 and 4p15.3. Reviewing the literature, we analyze and discuss the correlation between chromosomal balanced translocation regions and the pathogenesis of mental disorders. This aims to encourage psychiatrists to consider new perspectives on the diagnosis of schizophrenia.