摘要种植体周骨结合是成骨细胞和破骨细胞、骨组织和免疫系统功能耦联及平衡的结果.破骨细胞和异物巨细胞都起源于单核巨噬细胞系统.近年来单核巨噬细胞系统来源细胞在种植体周骨结合界面的存在、分布及其生物学作用的研究成果逐渐发表,证明这些亚型复杂、鉴定困难、功能多变的细胞对于种植体周骨结合的建立和长期维持具有重要作用,但由于许多仍未阐明的问题,使得如何利用其中的分子靶点仍是谜团.本文就种植体周骨结合中的单核巨噬细胞系统来源细胞及其功能的研究进展做一综述.

abstractsAlthough many studies have focused on how material surface modifications can promote stem cell differentiation toward osteogenic osteoblasts, little is known about the reaction between material surface and other cells, including osteoclasts and foreign body giant cells. Dental implant osseointegration results from the functional coupling and equilibrium not only between osteoblasts and osteoclasts but also between bone tissue and immune system. Osteoclasts and foreign body giant cells share the same origin, monocyte/macrophage lineage cells,which have initially got concerns in the field of implant osseointegration with regard to their peri-implant distribution and biological functions.Up-to-date data has shown that cells of monocyte/macrophage lineage origin manifest key roles in the establishment of peri-implant osseointegration and the long-term maintenance of marginal bone level and the prevalence of peri-implantitis. However, preliminary progress has been made in the subtypes,phenotypes vs.genotypes,and functions of monocyte/macrophage-lineage-originated cells on the osseointegration interface, quite a lot of facts still remain unclear, especially the potential and the rapeutic targets which could coordinate the cellular peri-implant microenvironment and the implant osseointegrated interface in the short and long term. This review will focus on the current progress in the function of monocyte/macrophage-lineage origin cells on the peri-implant osseointegration interface.