摘要目的 了解唾液腺肿瘤的发病情况及构成比例,为疾病诊断和治疗提供新思路.方法 收集吉林大学口腔医院病理科1961年1月至2016年12月间确诊的唾液腺肿瘤病例3 724例,病理类型参照第4版WHO头颈部肿瘤——唾液腺肿瘤组织病理学分类标准,用Microsoft Excel软件建立唾液腺肿瘤病例数据库,用SPSS 18.0统计软件进行数据分析,以8年为1个时间区间,在肿瘤类型、发病部位、患者性别、就诊年龄等方面对全部病例进行数量上的回顾性分析比较,并进行肿瘤发生趋势的判断.结果 各时间区间内良性肿瘤发生率均高于恶性,总体比例约为2.92∶1;良性肿瘤中发生率位居前三位的分别为多形性腺瘤[73.78％(2 046/2 773)]、沃辛瘤[15.80％(438/2 773)]和基底细胞腺瘤[8.37％(232/2773)],其中多形性腺瘤占全部良恶性肿瘤的54.94％(2 046/3 724);恶性肿瘤中前三位分别为黏液表皮样癌[31.44％(299/951)]、腺样囊性癌[26.92％(256/951)]和腺癌[11.88％(113/951)].男女唾液腺肿瘤的发生比例为0.83∶1;肿瘤发生部位以腮腺为主[63.75％(2 374/3 724)],其次为腭腺[16.50％(615/3724)]、下颌下腺[12.67％(472/3 724)];就诊年龄主要为51～ 60岁[23.74％ (884/3 724)]及41 ～ 50岁[21.56％(803/3 724)].结论 56年间唾液腺肿瘤的发生率呈上升趋势;女性唾液腺肿瘤发生率高于男性;腮腺是最好发部位;多形性腺瘤是最常见的唾液腺肿瘤;黏液表皮样癌是最常见的恶性唾液腺肿瘤;就诊年龄在各时间段上的分布较分散,51～ 60岁是相对集中的就诊年龄.

abstractsObjective To investigate the incidence and proportion of salivary gland tumors in order to provide new thinking for clinical diagnosis and treatment.Methods Collected 3 724 cases salivary gland tumors diagnosed by Pathology Department of Hospital of Stomatology,Jilin University from January 1961 to December 2016.The pathological diagnosis referred to the fourth edition of head and neck-salivary gland tumor histopathological classification standard of WHO.The database was established with Microsoft Excel and analyzed with SPSS 18.0.Made a retrospective analysis and comparison on the numbers of all cases in terms of types,site,gender and age and estimate the trend with the time interval of 8 years,and then make a judgement of the trend of salivary tumors.Results The benign tumors were more common than the malignant among all periods,the proportion of all tumors was about 2.92 ∶ 1;The top three benign tumors were polymorphous adenoma [73.78％ (2 046/2 773)],Warthin tumor [15.80％ (438/2 773)] and base cell adenoma [8.37％ (232/2 773)].Polymorphous adenoma took up 54.94％ (2 046/3 724) of all tumors.The top three malignant tumors were mucous epidermoid carcinoma [31.44％ (299/951)],adenoid cystic carcinoma [26.92％ (256/951)] and adenocarcinoma [11.88％ (113/951)].As for sex,male female ratio was 0.83 ∶ 1.As for site,the pathogenic site of tumors was mainly in parotid gland [63.75％ (2 374/3 724)],followed by palatal gland [16.50％ (615/3 724)],then submandibular gland [12.67％ (472/3 724)];As for age,the common age was between 51 and 60 years old [23.74％ (884/3 724)],followed by 41 to 50 years old [21.56％ (803/3 724)].Conclusions The incidence of benign and malignant salivary gland tumor increased in the 56 years.Females showed a higher incidence.The majority tumors occurred in parotid gland.The most common salivary gland tumor was pleomorphic adenoma and the most common malignant tumor was mucous epidermoid carcinoma.The most common age was in 51-60 years old period.