直接抗病毒药物在慢性丙型肝炎中的临床应用进展
Advances in direct-acting antiviral agents in treatment of chronic hepatitis C
摘要近年来,随着丙型肝炎病毒(HCV)生命周期研究的深入和直接抗病毒药物(DAAs)的获批,慢性丙型肝炎(CHC)的治疗取得了巨大的进展.该文总结了DAAs在CHC中的临床应用进展,显示根治HCV感染是完全可能的,但由于DAAs价格昂贵,因而在临床上推广受到限制.目前,聚乙二醇干扰素联合利巴韦林仍作为我国CHC患者的主要治疗手段,DAAs可作为重要补充.
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abstractsIn recent years, with the advances in life cycle of hepatitis C virus (HCV) and the approval of direct-acting antiviral agents (DAAs), great progress has been made in treatment of chronic hepatitis C (CHC).This article reviews the research progress of DAAs in CHC management, showing the possibility of the elimination of HCV infection by DAAs.DAAs have not been widely clinically used due to high medication costs, but can be used as a supplement for the combination therapy of pegylated interferon and ribavirin.
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