摘要抗菌药物的广泛应用使细菌耐药问题日益严重，多重耐药菌感染已成为重症感染者主要死亡原因之一。将药物在体内的药代动力学（Pharmacokinetics，PK）参数与体外药效学（Pharmacodynamics，PD）参数结合起来的 PK／PD 在提高抗菌药物疗效、阻断细菌耐药性产生等方面均具有重要意义。本文根据抗菌药物的 PK／PD 特点，就其在多重耐药菌感染的药物选择和应用等方面作一综述。

abstractsWith the wide use of antibiotics,the problems of drug-resistance are increasing seriously.Multi-drug resistant bacteria have become one of the major causes of death in patients with severe infections.The PK/PD parameters that combine pharmacokinetics parameters (PK ) in vivo with pharmacodynamic parameters (PD)in vitro play an important role in improving antimicrobial efficacy and suppressing antimicrobial resistance.This article reviews the selection of antibiotic regime based on the characteristics of PK/PD parameters and its application for patients with multidrug resistant bacterial infections.