摘要目的 研究母体哺乳期染毒氰戊菊酯对子代青春期雌鼠感觉运动行为和生活习性的影响.方法 将12只雌小鼠随机分成对照组、7.5和30.0 mg/kg氰戊菊酯染毒组(每组4只母鼠,每窝10只仔鼠,每组20只雌性仔鼠).于仔鼠出生后第1～21天(PND1～PND21)每天给予染毒组母鼠氰戊菊酯(7.5和30.0 mg/kg)灌胃染毒1次,对照组母鼠给予等容积玉米油.观察出生后第35天(PND 35 d)子代青春期雌鼠感觉运动行为和生活习性的变化.结果 与对照组[周边时间:(203.4±53.0)s和站立次数:(30.9±17.3)次]相比,30.0 mg/kg染毒组子代雌鼠[周边时间:(263.4±54.8)s和站立次数:(47.3±16.2)次]明显增加,差异均有统计学意义(P＜0.05).7.5 mg/kg染毒组子代雌鼠抓绳分值[(56.50±50.79)分]和30.0mg/kg染毒组子代雌鼠抓绳分值[(54.73±53.91)分]明显低于对照组[(114.53±53.87)分],差异均有统计学意义(F=4.141,P＜0.05).不同组别子代雌鼠平衡木分值、挖掘量、囤积量、筑巢分值比较,差异均无统计学意义(P＞0.05).结论 母体哺乳期染毒氰戊菊酯可导致子代青春期雌鼠探索和运动协调能力降低及焦虑行为增加,对生活习性无明显影响.

abstractsObjective To explore the effects of rat maternal exposure to fenvalerate during lactation on behaviors development in rat pubertal female offspring.Methods Twelve ICR matemal mice were randomly divided into 7.5 and 30.0 mg/kg fenvalerate exposure groups and control group (four dams each group,ten pups each darn,half male half female,twenty female pups each group).The exposure groups were orally exposed to fenvalerate at the doses of 7.5 and 30 mg/kg a day from postnatal day 1 (PND 1) to PND21.The control group was exposed to corn oil.The effects of maternal fenvalerate exposure during lactation on motor and species-typical behaviors in female offspring were observed on the PND 35.Results The peripheral time and standing frequency of 30.0 mg/kg exposure group were (263.4±54.8) s and (47.3±16.2) times,which were significantly higher than those [(203.4±53.0) s and (30.9±17.3) times] of control group (P＜0.05).The scores in 7.5 mg/kg and 30.0 mg/kg exposure groups were 56.50 ±50.79 and 54.73 ±53.91,respectively,which were significantly lower than that (114.53±53.87) in control group (P＜0.05).However,no significant differences in beam walking scores,food hoarding quantity,food digging quantity,and nest construction scores between two exposure groups were found (P＞0.05).Conclusion The rat maternal exposure to fenvalerate during lactation could decrease the ability of exploration and motor condition and increase the anxiety but not affect life habit in rat pubertal female offspring.