摘要目的 对新型高能量化合物3,4二呋咱基氧化呋咱(DNTF)的致畸性进行研究,为研究DNTF对人体健康影响和制订职业接触限值提供依据.方法 采用大鼠标准致畸试验,将受孕SD大鼠随机分为3个染毒组(剂量分别为5.0、15.8、50.0 mg/kg)、阴性对照组(植物油)和阳性对照组(环磷酰胺10.0 mg/kg),每组10～15只,对孕鼠于孕期7～12d每天灌胃染毒1次,共6d,妊娠第20天处死,检查孕鼠妊娠与胎鼠畸形情况.结果 与阴性对照组比较,3个染毒组的孕鼠体重、胎重、胎鼠生长发育、胎鼠畸形率、胎鼠骨骼和内脏畸形率的差异均无统计学意义(P＞0.05).结论 DNTF在5.0～50.0 mg/kg 染毒剂量范围内对大鼠无明显的母体毒性、胚胎毒性和致畸性.

abstractsObjective To study the teratogenicity of new high-energy compounds,3,4 two furazanbased oxidation furazan (DNTF) and the impacity on human health,occupational exposure limits were provided for the following research.Methods Pregnant SD rats were randomly divided into five groups by Standard teratogenicity test,including three dose groups (5.0,15.8,50.0 mg/kg),the negative control (vegetable oil),and the positive control group (CP 10.0 mg/kg).Each 10 to 15 rats were in one group.Gavage was consecuted for ratsduringpregnancy 7～12 d and then sacrifice after 20d.Results There were no significantly difference between the three dose groups and negative controls in the pregnancy rate,the weight of pregnant rats,fetal weight,fetal growth,fetal malformation rate and internal organs,Conclusion There were no maternal toxicity,embryo toxicity and teratogenicity for rats when DNTF in the range 5.0～50.0 mg/kg.