摘要目的 探讨民警职业应激与血清中免疫球蛋白(IgG、IgM和IgA)和补体(C3和C4)浓度的关系.方法 2011年5月,以方便抽样与整群抽样的方法抽取某市公安局某派出所的225名在职民警为研究对象.采用问卷调查其人口统计学特征和职业应激情况,采用免疫比浊法对血清中IgG、IgM、IgA和补体C3、C4的浓度进行检测.结果 正性情绪与IgG浓度呈正相关(r=0.084,P＜0.01);正性情绪、应付策略和睡眠质量与IgM浓度呈正相关(r=0.146、0.155和0.203,均P＜0.05),负性情绪与IgM浓度呈负相关(r=-0.185,P＜0.05);回报和睡眠质量与C3浓度呈正相关(r=0.172、0.285,均P＜0.05),负性情绪与C3浓度呈负相关(r=-0.174,P＜0.05);睡眠质量与C4浓度呈正相关(r=0.173,P＜0.05),负性情绪与C4浓度呈负相关(r=-0.164,P＜0.05).Logistic回归分析显示,社会支持和正性情绪高评分组导致IgG浓度降低的风险分别是低评分组的0.460、0.495倍,应付策略高评分组导致IgM浓度降低的风险是低评分组的0.482倍.结论 职业应激与血清中免疫球蛋白和补体浓度之间存在相关性.

abstractsObjective To investigate the correlation of occupational stress with the serum levels of immunoglobulins(IgG,IgM,and IgA) and complement(C3 and C4).Methods In May 2011,convenience sampling and cluster sampling were used to select 225 policemen from a local police station as study subjects.A questionnaire was used to investigate demographic features and occupational stress,and the immunoturbidimetric assay was applied to measure the serum levels of IgG,IgM,IgA,and complement C3 and C4.Results Positive affectivity was positively correlated with the concentration of IgG(r=0.084,P＜0.01);positive affectivity,coping strategy,and sleep quality were positively correlated with the concentration of IgM (r=0.146,0.155,and 0.203,all P＜0.05);negative affectivity was negatively correlated with the concentration of IgM(r=-0.185,P＜0.05).Reward and sleep quality were positively correlated with the concentration of C3 (r=0.172 and 0.285,both P ＜0.05),and negative affectivity was negatively correlated with the concentration of C3 (r=-0.174,P＜0.05);sleep quality was positively correlated with the concentration of C4 (r=0.173,P＜0.05),and negative affectivity was negatively correlated with the concentration of C4 (r=-0.164,P＜0.05).The logistic regression analysis revealed that the risks for a reduced concentration of IgG in the groups with high scores of social support and positive affectivity were 0.460 and 0.495 times those in the groups with low scores,while the risk for a reduced concentration of IgM in the group with a high score of coping strategy was 0.482 times that in the group with a low score.Conclusion Occupational stress is correlated with the serum levels of immunoglobulins and complement.