摘要目的 观察雌激素治疗萎缩性阴道炎患者后阴道局部环境的变化. 方法 对128例萎缩性阴道炎患者采用雌激素软膏阴道用药治疗,前瞻性开放用药前后自身对照,观察治疗效果.结果 治疗后阴道pH值显著下降,乳酸杆菌检出率明显升高(P＜0.01);平均阴道健康评分明显升高(P＜0.01).治疗后阴道分泌物白细胞介素6含量显著下降(P＜0.01);干扰素(INF)-γ含量较治疗前升高,但差异无统计学意义(P＞0.05). 结论 雌激素可明显改善萎缩性阴道炎患者的阴道局部环境,雌激素可能通过逆转Th1/Th2平衡紊乱,调节阴道的免疫功能.

abstractsObjective To investigate the change of local vaginal microenvironment in atrophic vaginitis after estrogen therapy.Methods A prospective study was conducted in 128 patients with atrophic vaginitis.The patients were treated with estriol cream by vaginal administration,and the efficacy was observed after treatment.Results The PH value was decreased and the detection rate of lactobacilli was significantly increased after estrogen therapy(P＜0.01).Average vaginal health score was also increased (P＜0.01).Interleukin-6 (IL 6) level in vaginal secretion was decreased after the treatment (P＜0.01).Interferon-γ (INF-γ) level was increased obviously after treatment,while there was no significant difference between the two groups(P＞0.05).Conclusions Estrogen can significantly improve the local vaginal microenvironment in atrophic vaginitis.Estrogen may regulate the immune function of vagina by reversing the imbalance of Th1/Th2.