摘要帕金森病(Parkinson disease, PD)是中老年常见的神经系统变性疾病,虽然经过多年的研究,其具体的发病机制尚不完全明确.近年来,越来越多的证据提示自噬在PD的发病机制中起着重要的作用.而最近PD遗传学研究的进展是发现了数个新的致病基因,部分在散发性PD中发挥作用,其中多个PD致病基因已被证实参与自噬的过程.现讨论与PD致病基因相关的自噬-溶酶体系统功能障碍,期望从整体上阐述PD的发病机制,为其治疗提供线索.

abstractsParkinson's disease(PD)is a common neurodegenerative disease mainly affecting old persons.The pathogenesis of PD is still unclear, although it has been studied for many years.Recently, more and more evidences show that the dysfunction of autophagy plays a pivotal role in the pathogenesis of PD.Substantial progress in the genetic research of PD has showed that several pathogenic genes were identified correlated with autophagy, in particular, playing an important role in sporadic cases of PD.Here, we will discuss pathogenic genes-correlated dysfunctional autophagy-lysosomes system, so as to specify the pathogenesis of PD and provide a clue for its treatment.