摘要目的 探讨局部扩大切除术联合艾拉光动力治疗老年阴囊Paget病的安全性与有效性.方法 2014年6月到2018年2月通过局部扩大切除术联合艾拉光动力治疗我院老年阴囊Paget病患者并进行随访,患者平均(68.4±4.7)岁,所有患者先行皮肤局部扩大切除术,病检明确为Paget病后纳入光动力治疗研究,2例患者因各种原因拒绝后期光动力治疗,2例患者光动力治疗后失访,均被剔除该研究.最终16例患者纳入研究,其Ray分期为:A1期6例、A2期7例、B期3例.术后予以艾拉光动力治疗3个疗程,然后对其疗效及近中期并发症情况进行随访.结果 16例患者最终确诊时病程为4～76个月,平均确诊时间为35.7个月,确诊后即行手术治疗,其中切除缝合10例,通过转移皮瓣治疗6例,其中3例行可疑淋巴结清扫,最终1例因皮瓣坏死感染而行二期手术治疗.对创面进行艾拉光动力治疗后进行了3个月到3年6个月的随访,2例出现复发并远处转移(1例脑转移,1例全身转移),综合复发率为12.5％.随访过程中除1例(6.3％)出现下肢活动障碍外未见其他严重并发症.结论 通过局部扩大切除术联合艾拉光动力的综合治疗对老年阴囊Paget病具有较好临床效果和较低的复发率及并发症发生率.

abstractsObjective To investigate the safety and efficacy of wide local excision surgery combined with 5-aminolaevulinic acid(ALA)-photodynamic therapy(PDT)in treating Paget's disease of the scrotum in elderly people.Methods Patients with an average age of 68.4 ± 4.7 years undergoing wide local excision surgery combined with ALA-PDT for Paget's disease of the scrotum from June 2014 to February 2018 were followed up.All patients underwent wide local excision surgical treatment first and were then enrolled in ALA-PDT study after the diagnosis of Paget's disease of the scrotum was confirmed.Four cases were eliminated as a result of two patients refusing photodynamictherapy for various reasons and two patients lost during follow-up after ALA-PDT.A total of 16 patients were included in the study,of whom 6 cases were in Ray stage A1,7 cases in stage A2 and 3 cases in stage B.Patients underwent 3 courses of ALA-PDT after operation.Then the efficacy,shortand medium-term complications were followed up.Results The duration of disease among the 16 patients ranged from 4 to 76 months before diagnosis,with an average of 35.7 months.Surgery was performed immediately after diagnosis.Ten patients underwent resection and suture and 6 patients were treated with skin flap transfers.Of the patients treated with surgery,3 patients received suspicious lymph node dissection and 1 patient underwent reoperation due to skin flap necrosis.Patients were followed up for 3 months to 3 years and 6 months after ALA-PDT.Recurrence and distant metastasis occurred in 2 cases,with 1 case of brain metastasis and 1 case of systemic metastasis,and the overall recurrence rate was 12.5％.During the follow-up,there were no other serious complications except for 1 case(6.3 ％)with lower limb movement disorders.Conclusions Wide local excision surgery combined ALA-PDT has good clinical outcomes,low recurrence rates and few complications for the treatment of Paget's disease of the scrotum in elderly people.