摘要目的 观察光动力疗法治疗老年口腔白斑病患者的临床疗效. 方法 前瞻性研究,使用5-氨基酮戊酸(5-aminolevulinic acid,ALA)光动力疗法(photodynamic therapy,PDT)对15例老年口腔白斑病患者进行治疗,敷药2h后,应用波长635 nm的半导体激光照射,激光功率密度300mW/cm2,每个病灶照射6 min,能量密度100 J/cm2.观察病损变化,评价疗效和记录不良反应.结果 15例患者15处病灶,其中4处病灶经1次治疗,3处病灶经2次治疗,6处病灶经3次治疗,2例患者经过4次治疗后痊愈.平均治疗(2.4±1.1)次.术后出现的不良反应为疼痛.视觉模拟评分法(VAS)术后疼痛平均分数为(2.2±0.8)分,术后疼痛持续时间为(2.6±1.1)d.术后3～9个月复查未见复发,患者无口腔感觉和功能的异常. 结论 光动力疗法是治疗老年口腔白斑病患者的有效方法.

abstractsObjective To observe the clinical efficacy of photodynamic therapy on oral leukoplakia in elderly patients.Methods In this prospective study,fifteen elderly patients with oral leukoplakia were treated with 5 aminolevulinic acid-based photodynamic therapy(ALA PDT).After 2 hours of dressing,patients were irradiated using a 635nm semiconductor laser with the power density of 300mW/cm2.Each lesion was irradiated for 6 minutes with energy density of 100J/cm2.The curative effect was evaluated and the adverse reactions were recorded based on the observation of lesion changes.Results Of the 15 lesions in 15 patients,4 lesions were treated once,3 lesions were treated twice.And 6 lesions were cured after three treatments,and 2 patients were cured after four treatments.The average treatment frequency was (2.4 ± 1.1) treatment.The postoperative adverse reaction was pain.The average visual analogue scale was (2.2 ± 0.8) scores after operation,and the duration of pain was(2.6±1.1)days after operation.There was no recurrence for 3 to 9 months after operation.No abnormalities of oral sensation and function were found in patients.Conclusions ALA-PDT is an effective method for the treatment of oral leukoplakia in elderly patients.