摘要细胞外囊泡是脂质双分子层包绕形成的球状膜性囊泡，由多种细胞分泌并释放到细胞外环境中，包括外泌体、微粒和凋亡小体，是一种新的细胞间通讯方式，且作为生物标记物可指征多种疾病。然而，细胞外囊泡是如何随着年龄变化的，以及导致这些变化的潜在机制还不清楚。本文总结了细胞外囊泡的研究现状，重点讨论了细胞外囊泡与衰老之间的关系及其在衰老相关性疾病中的作用，并进一步阐述了其在衰老相关治疗方面的应用，为干预衰老过程及治疗衰老相关性疾病提供新思路。

abstractsExtracellular vesicles are spherical membrane vesicles formed by bimolecular lipid layers and are secreted and released into the extracellular environment by many kinds of cells.Extracellular vesicles include exosomes, microparticles and apoptotic bodies, which represent newly discovered ways of intercellular communication and can be used as biomarkers to distinguish a variety of diseases.However, how extracellular vesicles change with age and the underlying mechanisms for these changes are not clear.This article reviews current research on extracellular vesicles, with a focus on the relationship between extracellular vesicles and aging and its role in aging-related diseases.Furthermore, its practical application in aging is also discussed, in order to provide new ideas for the intervention of the aging process and the treatment of aging-related diseases.