摘要绝经泌尿生殖综合征(GSM)患者由于雌激素的下降，导致阴道环境的变化，包括阴道组织结构、阴道微生物群和阴道黏膜免疫的改变，从而出现一系列症状和体征。制定针对GSM的有效治疗方法，需要全面理解这些变化的潜在分子机制。间充质干细胞(MSCs)具有促进衰老组织再生、高生长因子分泌活性、优异的免疫调节和抗炎能力，是针对生殖衰老的一种有力的候选治疗。因此，有必要了解GSM患者的阴道环境变化及MSCs的应用进展，为GSM的治疗研究提供参考。

abstractsDue to decreased estrogen levels in patients with genitourinary syndrome of menopause(GSM), changes occur in the vaginal environment, including changes in vaginal tissue structure, the vaginal microbiota and vaginal mucosal immunity, resulting in a series of symptoms and signs.To develop effective treatment methods for GSM, it is necessary to fully understand potential molecular mechanisms underlying these changes.Mesenchymal stem cells(MSCs)can promote the regeneration of aging tissues, secrete growth factors, and have excellent immune regulation and anti-inflammatory capabilities.They are a powerful treatment option for reproductive aging.Therefore, it is essential to understand changes of the vaginal environment in GSM patients and progress on the use of MSCs as an intervention, in order to gain insight into research on the treatment of GSM.