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摘要采用酶联免疫法（ELISA）检测127例慢性肝病患者血清中的HBV、HCV和HDV感染标志，并采用逆转录—聚合酶链反应（RT-PCR）技术检测部分患者血清HCV-RNA。HBV、HCV和HDV混合感染共37例（29.1%）。混合感染者发生慢重肝的频率明显高于单独HBV感染者（P＜0.05），混合感染占慢重肝病因的74.2%。混合感染所致慢重肝患者的凝血酶原时间、血清总胆红素及病死率明显高于单独HBV感染者。结果表明：HBV、HCV和HDV混合感染可能是慢性肝病重型化的主要原因，所致慢重肝患者的病情重、预后差。

abstractsSerum samples from 127 patients with chronic liver diseases (CLD) were tested for HBV markers, anti-HCV and HDV markers by enzyme-linked immunosorbent assay (ELISA). The serum samples from some patients were detected for HCV-RNA by reverse transcription and polymerase chain reaction (RT-PCR) technique. The results showed that 85.7% of chronic persistent hepatitis (CPH), 71.0% of chronic active hepatitis (CAH) and 73.9% of liver cirrhosis (LC) were caused by HBV infection only. In 127 patients with CLD, 37(29.1%) were multiple infections with HBV, HCV and HDV. The incidence of patients with chronic severe hepatitis (CSH) was significantly higher in multiple infections than in HBV infection only (P<0.05). 74.2% of CSH were caused by multiple infections. The average levels of serum bilirubin and prothrombin time in patients with CSH caused by multiple infections were significantly higher than those in patients caused by HBV infection only (P<0.05). The mortality rate of patients with CSH caused by multiple infections was significantly higher than that of cases by HBV infection only (P<0.05).Based on our data, it is concluded that multiple infctions with HBV, HCV and HDV might be the major factor leading to the aggravation of CLD. The general condition and prognosis of patients with CSH caused by multiple infections were much worse than those of cases caused by HBV infection only. In China HBV is a major agent of chronic hepatitis and liver cirrhosis.