摘要目的 探讨北京市远郊农村40岁以上人群颅内外动脉狭窄患病率、卒中发病风险及相关危险因素.方法 整群抽样调查北京市远郊农村40岁以上人群1337例,经颅多普勒检查发现颅内外动脉狭窄89例.在平均16.7个月时对所有人群进行电话及入户随访,调查卒中发病情况.结果 1337例调查对象颅内外动脉狭窄的患病率为6.6%.其中颅内动脉狭窄5.8%、颅外动脉狭窄0.4%、颅内外动脉同时狭窄0.4%.平均16.7个月随访期内,无颅内外动脉狭窄者的脑梗死、脑出血发病密度分别为410.6、351.9/10万人年;颅内外动脉狭窄患者的脑梗死发病密度为3303.7/10万人年,无发生脑出血者;颅内外动脉狭窄组与无颅内外动脉狭窄组之间脑梗死发病差异具有统计学意义(P=0.004).脑梗死发病危险因素的logistic回归分析显示颅内外动脉狭窄(OR=6.593,95%CI:1.712～25.390,P<0.01)、吸烟(OR=8.437,95%CI:2.327～30.598,P<0.01)是脑梗死发病的独立危险因素.结论 颅内外动脉狭窄患者的脑梗死发病密度为3303.7/10万人年,明确无脑梗死或短暂性脑缺血发作病史的颅内外动脉狭窄患者的脑梗死发病密度为2799.6/10万人年,颅内外动脉狭窄、吸烟史是脑梗死发病的独立危险因素.

abstractsObjective To assess the prevalence rates of intra-and extraeranial large-artery stenosis in the rural community population and its related risk to the development of stroke.Methods The study subjects included 1337 residents in the rural community of Beijing.Transcranial Doppler Was carried our to examine the relation between intra-and extracranial large-artery stenosis and subsequent cerebrovascular events, with a meall follow-up period of 16.7 months.Results The incidence densities of cerebral infarction and cerebral hemorrhage in persons without cerebral large-artery stenosis were 410.6 and 351.9/100-thousand person-years,respectively.In the group wlth large-artery stenosis,the incidence density of cerebral infarction was 3303.7/100-thousand person-years.Data from The Fisher's Exact test showed a significant difference in the two groups (P=0.004).Cerebral large-artery stenosis(OR=6.593,95%CI:1.712-25.390)and smoking (OR=8.437,95% CI:2.327-30.598)appeared to be independent risk factors to cerebral infarction.Conclusion Cerebral large-artery stenosis and smoking were independent risk factors to cerebral infarction.