摘要目的 了解广东省健康人群手足口病病原隐性感染情况.方法 在广东省7个市随机抽取7个年龄组健康儿童及成年人,采集粪便标本进行手足口病病原检测.结果 7个市共采集1285份样本,肠道病毒71型(EV71)阳性率为0.39％(5/1285),柯萨奇病毒A组16(CA16)阳性率为0.23％(3/1285),其他肠道病毒阳性率为7.00％ (90/1285).4～6岁年龄组EV71阳性率最高,为1.79％ (4/223),其次为0～3岁年龄组,为0.67％(1/223),其余年龄组均未检出EV71；只有4～6岁年龄组检出CA16,阳性率为1.35％ (3/223).所有EV71阳性标本均在本地户籍人群中检出,阳性率为0.47％(5/1063)；CA16在本地户籍人群(0.19％)和外地户籍(0.85％)中均有检出,差异无统计学意义(P＞0.05).农村和城市EV71的阳性率分别为0.36％和0.54％,差异无统计学意义(P＞0.05)；所有CA16阳性标本均在城市儿童中检出.结论 广东省健康人群中仅6岁以下年龄组检出EV71和CA16阳性,健康成年人中未检出EV71和CA16阳性,应重点对儿童尤其是学龄前儿童采取有效防控措施.

abstractsObjective To understand the pathogen-carrying status of hand-foot-mouth disease (HFMD) among healthy people in Guangdong province.Methods Stool specimens were collected randomly on 7 age groups from 7 cities in Guangdong province.Real-time RT-PCR was used to detect enterovirus (EV),enterovirus 71 (EV71) and coxsackie virus A16 (CA16).Results Altogether,1285 stool specimens were collected.The positive rates of EV71,CA16 and other enterovirus were 0.39％ (5/1285),0.23％ (3/1285) and 7.00％ (90/1285),respectively.The highest EV71 positive rate (1.79％) was among the 4-6-year-old group,followed by the age group 0-3 with positive rate as 0.67％.EV71 was not found among the rest age groups.The highest CA16 positive rate (1.35％) was among the 4-6 year-olds group,but the CA16 was not found among the rest age groups.EV71 was only found among native population,with the positive-rate as 0.47％.CA16-positive rate was 0.19％ among the native population and 0.85％ among floating population,with no significant difference found (P＞0.05).The EV71 positive rate was 0.36％ among rural residents and 0.54％ among urban residents,but with no significant difference (P＞0.05).All CA16 was found among the urban residents.Conclusion Recessive infection of EV71 and CA16 were only found among 0-6 year-old group but not found among other groups,which suggested that the approaches on prevention and control should be targeted to all children especially on pre-school children.