摘要目的 评估生命早期暴露于饥荒对现时肝肾脏功能指标水平的影响,探讨肝肾功能体检指标是否可能作为评价宫内胎儿器官发育的生物标志物.方法 整群抽取2011年安徽省某三级甲等医院健康体检中心1957-1963年出生的体检者4 252人.按照出生时间将研究对象分为3个组.即1957-1958年出生者983人为饥荒前暴露组;1959-1961年出生者1 247人为饥荒暴露组;1962-1963年出生者2 022人为饥荒后对照组.采用方差分析比较组间丙氨酸氨基转移酶(ALT)、谷氨酰基转移酶(r-GGT)、天门冬氨酸转移酶(AST)、直接胆红素(DBIL)、间接胆红素(IBIL)、总胆红素(TBIL)、血浆白蛋白(ALB)、球蛋白(GLB)、总蛋白(TP)、血肌酐(SCr)、尿酸(UA)、尿素氮(UREA)水平的差异及变化趋势.结果 不同年份出生的研究对象ALT、IBIL、TBIL、SCr、UREA水平的差异有统计学意义(P＜0.05);不同年份出生的男性其r-GGT、ALT、AST、ALB、SCr水平的差异有统计学意义(P＜0.05),不同年份出生的女性其r-GGT、AST、ALB、GLB、TP、SCr、UA、UREA水平的差异有统计学意义(P＜0.05);男性中饥荒暴露组r-GGT、ALT、ALB、TP水平高于饥荒前暴露组,差异有统计学意义(P＜0.05).女性中饥荒暴露组r-GGT、ALB、TP、SCr、UREA、UA水平高于饥荒后对照组,差异有统计学意义(P＜0.05).结论 生命早期营养缺乏可能导致器官发育障碍、功能受损,对成年后肝肾功能产生影响,且可能存在性别差异.孕期女性合理膳食均衡营养对预防其子代成年后慢性代谢性疾病有深远意义.

abstractsObjective To examine how early life exposure to famine would impact on liver and kidney functions and related chronic metabolic diseases during adulthood.Methods A random cluster sampling method was adopted in Anhui province,2011 from a physical examination center,in a first-class hospital.4 252 study subjects were born between 1957 and 1963.According to the time of birth:the study subjects were divided into three groups,respectively:1957-1958 (983 persons as pre-famine),1959-1961 (1 247 persons as exposed to famine) or 1962-1963 (2 022 persons as controls,also the post-famine).Variances between groups AST,ALT,r-GGT,differences in the levels of SCr,UA,UREA and the change trend were compared.Results ALT,IBIL,TBIL,SCr,UREA were statistically different (P＜0.05) among subjects born in the different years.r-GGT,ALT,AST,ALB,SCr were statistically different (P＜0.05) among males bornin different years so as the r-GGT,AST,ALB,GLB,TP,SCr,UA,UREA in females (P＜0.05).r-GGT,ALT,ALB,SCr differences statistically significant (P＜0.05) and r-GGT,AST,ALB,GLB,TP,SCr,UA,UREA in females were statistically significantly different (P＜0.05).Conclusion Early life poor nutrition could lead to developmental disorders,organ function damage in liver and kidney function during adulthood.Women appeared to have balanced diet nutrition during pregnancy which was far important in the prevention on adulthood chronic metabolic diseases.