摘要目的 探索采用同伴推动抽样法(Respondent-Driven Sampling,RDS)开展MSMHIV监测的可行性及该人群HIV感染趋势分析.方法 2005-2012年每年4-10月采用RDS法在北京征募MSM开展调查,了解目标人群人口学特征、艾滋病相关危险行为以及HIV和梅毒感染状况.结果 2005-2012年各调查427,540,607,614,616,602,579和600名MSM.HIV感染率由2005年的4.2％(95％CI:1.9～7.0)上升至2012年的10.1％(95％CI:7.2～13.2,P=0.02).外地户籍、25岁以上和高中及以下教育水平MSM HIV感染率人群估计分别从3.3％(95％CI:1.8～5.4)、6.4％ (95％CI:2.2 ～ 9.5)和5.5％(95％CI:2.2～ 8.9)升至2012年的10.7％(95％CI:7.8～ 14.6,P=0.04)、7.6％(95％CI:5.4 ～ 10.3,P=0.04)和10.4％(95％CI:7.2～ 14.3,P=0.04).25岁及以下者和高中以上文化程度者HIV感染率分别自2009和2007年起开始上升,从1.7％(95％CI:0.4～3.1)和1.1％(95％CI:0.2 ～ 1.7)升至13.7％(95％CI:7.2～ 20.4)和9.1％(95％CI:4.7～ 13.8),未达显著性水平.最近6个月有2～9名男性伴者HIV感染率由2005年的4.0％(95％CI:1.0～8.0)上升至2012年的12.6％ (95％CI:8.7～16.7,P=0.02).结论 RDS是一种稳定性较高的隐匿人群抽样方法,可用于长期监测.2005-2012年北京市MSM人群HIV感染率呈上升趋势,应重点关注MSM人群中的年轻人及高学历者.

abstractsObjective To understand the HIV prevalence among men who have sex with men (MSM) and discuss the feasibility of respondent driven sampling (RDS) as a tool to conduct long term HIV surveillance in MSM in Beijing.Methods From 2005 to 2012 RDS was used to recruit MSM for face-to-face interview with structured questionnaire to collect their demographic characteristics and HIV risk-related behavior.Blood samples were collected from them for HIV test.Results A total of 427,540,607,614,616,602,579 and 600 MSM were surveyed,respectively,from 2005 to 2012.The HIV infection prevalence increased from 4.2％ (95％ CI:1.9-7.0) in 2005 to 10.1％ (95％ CI:7.2-13.2) in 2012 (P=0.02).Meanwhile,HIV prevalence substantially increased among MSM aged ＞ 25 years,in floating population and with lower education level (≤high school),from 6.4％(95％CI:2.2-9.5),3.3％(95％CI:1.8-5.4) and 5.5％ (95％CI:2.2-8.9) in 2005 to 7.6％ (95％CI:5.4-10.3,P=0.04),10.7％ (95％ CI:7.8-14.6,P=0.04) and 10.4％ (95％ CI:7.2-14.3,P=0.04) in 2012,respectively.Moreover,the HIV infection prevalence in MSM aged ≤25 years old and with higher education level (＞high school) increased from 1.7％(95％ CI:0.4-3.1) in 2009 and 1.1％(95％ CI:0.2-1.7) in 2007 to 13.7％(95％CI:7.2-20.4) and 9.1％(95％CI:4.7-13.8) in 2012,respectively,the differences were not significant.Furthermore,the HIV infection prevalence in MSM who had 2-9 male sex partners in the last six months increased from 4.0％ (95％CI:1.0-8.0) in 2005 to 12.6％ (95％CI:8.7-16.7) in 2012 (P=0.02).Conclusions Studies have shown that RDS is an effective and feasible sampling method for long term HIV surveillance in MSM.The HIV infection prevalence in MSM in Beijing increased from 2005 to 2012,especially among those with older age,in floating population and with lower educational level.More attention should be paid to MSM with younger age and with higher educational level.