摘要目的 探讨陕西省新生儿体表先天畸形的影响因素.方法 采用分层多阶段随机抽样方法,通过问卷调查2010-2013年陕西省孕满28周且结局明确的育龄妇女及其生育子女的相关信息,采用多因素logistic回归分析新生儿体表先天畸形的影响因素.结果 多因素logistic回归分析结果显示,妊娠期肝内胆汁淤积症(OR=21.76,95％CI:4.46～ 106.25)、不良孕产史(OR=11.88,95％CI:9.14 ～ 15.45)、家族出生缺陷史(OR=6.15,95％CI:2.66～ 14.23)、双胎(OR=5.74,95％CI:3.34～9.86)、母亲为工人(与其他职业比,OR=2.47,95％CI:1.30～ 4.68)或农民(与其他职业比,OR=1.91,95％CI:1.14 ～ 3.20)、产检＜4次(与产检＞7次者比,OR=1.84,95％CI:1.28～2.64)、职业危险暴露(OR=1.74,95％CI:1.26～ 2.42)、母亲来自关中地区(与陕北地区者比,OR=1.65,95％CI:1.20 ～ 2.28)、母亲居住农村(OR=1.75,95％CI:1.13 ～ 2.71)、围孕期使用药物(OR=1.64,95％CI:1.26～2.13)是体表先天畸形的危险因素,而母亲围孕期服用铁剂(OR=0.46,95％CI:0.21～0.99)是体表先天畸形的保护因素.结论 母亲来自关中地区、农村、农民或工人、不良孕产史、家族出生缺陷史、双胎、产检＜4次、职业危险暴露、使用药物、妊娠期患肝内胆汁淤积症可能增加新生儿体表先天畸形的罹患风险.

abstractsObjective To investigate the influencing factors on congenital malformation of body surface.Methods Multi-stage stratified random sampling method was adopted.A questionnaire survey was conducted among the childbearing aged women who experienced more than 28 weeks pregnancy or having defmite pregnancy outcomes in Shaanxi,during 2010-2013.Results Results from the logistic regression model showed that factors as:intrahepatic cholestasis of pregnancy (OR=21.76,95％CI:4.46-106.25),histories with abnormal pregnancy or reproduction (OR=11.88,95％CI:9.14-15.45),having birth defects in the family (OR=6.15,95％CI:2.66-14.23),being twins (OR=5.74,95％CI:3.34-9.86),being worker (compared with others,OR=2.47,95％CI:1.30-4.68) or farmer (compared with others,OR=1.91,95％CI:1.14-3.20),less than 4 times of antenatal care (compared with ＞7,OR=1.84,95％ CI:1.28-2.64),occupational exposure to related risks during pregnancy (OR=1.74,95％CI:1.26-2.42),mother's hometown was from mid-part of Shaanxi (compared with northern Shaanxi,OR=1.65,95％CI:1.20-2.28),mother's native residence was from the rural areas (OR=1.75,95％CI:1.13-2.71),drug use (OR=1.64,95％CI:1.26-2.13) etc.were risk factors for congenital malformation of body surface.Iron supplement during pregnancy (OR=0.46,95％ CI:0.21-0.99) appeared as protective factor for congenital malformation of body surface.Conclusion The following factors seemed to be of risk for congenital malformation of body surface,including:mother's native area was from the middle part of Shaanxi and living in rural area,being worker or farmer,histories of abnormal pregnancy and reproduction,history of birth defects in the family,being twins,with antenatal care less than 4 times,occupational exposure to dangerous materials,drug use,intrahepatic cholestasis during pregnancy etc.