摘要目的 采用Meta分析方法系统评价2007-2016年中国59岁以下普通人群HBsAg阳性率的变化趋势.方法 通过中国知网(CNKI)、维普中文科技期刊全文数据库(vIP)及PubMed,系统检索2007年1月至2016年8月中国59岁以下普通人群HBsAg阳性率的文献,采用comprehensive Meta-analysis 2.2软件,运用固定效应模型和随机效应模型合并分析59岁以下普通人群HBsAg阳性率.结果 共纳入文献46篇,总样本量625 053例,Meta分析结果显示中国59岁以下普通人群HBsAg阳性率为5.7％(95％CI:4.8％～6.6％).中西部地区59岁以下普通人群HBsAg阳性率为6.3％(95％CI:4.9％～8.0％),高于东部地区的5.5％(95％CI:4.4％～ 6.8％).59岁以下男性人群HBsAg阳性率为6.1％(95％CI:5.3％～7.0％),高于女性人群的4.8％(95％CI:4.2％ ～5.5％).2007-2009年的59岁以下普通人群HBsAg阳性率为6.3％(95％CI:5.5％ ～ 7.2％),2010-2012年为5.9％ (95％ CI:4.4％ ～ 8.0％),2013-2016年为3.5％(95％CI:2.0％～6.1％).结论 2007-2016年中国59岁以下普通人群HBsAg阳性率呈现下降趋势,已经从乙型肝炎高流行区转变为乙型肝炎中流行区.

abstractsObjective To perform a Meta-analysis on hepatitis B surface antigen (HBsAg)-positive rates among general Chinese population aged 1-59 years.Methods We systemically reviewed the related data (January 2007 to August 2016) published from Chinese National Knowledge Infrastructure (CNKI),VIP,and PubMed.We also assessed the HBsAg-positive rates among general Chinese populations aged 1-59 years,using a random effects regression model with the comprehensive Meta-analysis software 2.2.Results A total of 46 papers were finally included,with a total sample size of 625 053 individuals.Results from the Meta-analysis showed that the overall combined HBsAg-positive rate was 5.7％ (95％CI:4.8％-6.6％) among general Chinese populations aged 1-59 years.When comparing the HBsAg-positive rates in different regions,data showed that the HBsAg-positive rate of was higher in the mid-western areas (6.3％,95％CI:4.9％-8.0％)than in the eastern areas (5.5％,95％CI:4.4％-6.8％).Results showed that HBsAg-positive rates was higher in males (6.1％,95％CI:5.3％-7.0％) than in females (4.8％,95％CI:4.2％-5.5％).As for the HBsAg-positive rates in different time periods,data showed positive rate of 6.3％ (95％CI:5.5％-7.2％)in 2007-2009,5.9％ (95％CI:4.4％-8.0％) in 2010-2012 and 3.5％ (95％CI:2.0％-6.1％) in 2013-2016,respectively.Conclusion The prevalence of hepatitis B virus infection was decreasing between 2007 and 2016 in China,making the country an intermediate endemic area on HBV.