摘要目的 了解上海市艾滋病自愿咨询检测(VCT)门诊就诊MSM人群HIV与梅毒、单纯疱疹病毒2型(HSV-2)共感染情况及其可能影响因素.方法 采用横断面研究设计,用方便抽样法选取上海市与普陀区的2个VCT门诊,于2015年3-8月招募≥18岁、最近1年发生过同性插入性性行为的MSM作为调查对象,招募756名MSM,使用x2检验和logistic回归法分析.结果 共调查732名MSM,调查对象HIV与梅毒共感染率为3.3％(24/732),HIV与HSV-2共感染率为1.9％(14/732),HIV与梅毒、HSV-2共感染率为0.7％(5/732).梅毒感染者的HIV感染率45.3％(24/53)显著高于非梅毒感染者7.2％(61/679) (x2=63.11,P＜0.001);HSV-2感染者的HIV感染率34.1％(14/41)显著高于非HSV-2感染者10.3％(71/691)(x2=21.49,P＜0.001).多因素logistic回归分析显示,调查对象HIV与梅毒共感染的可能危险因素包括外地户籍(OR=3.50,95％CI:1.01～12.17)、初中及以下文化程度(OR=4.46,95％CI:1.54～ 12.87)和曾使用毒品(OR=4.25,95％CI:1.67 ～ 10.82);HIV与HSV-2共感染的可能危险因素:高中及以下文化程度(OR=6.87,95％CI:1.86 ～ 25.42;OR=9.82,95％CI:2.25～42.85).结论 上海市VCT门诊就诊的MSM中存在一定比例的HIV和梅毒、HIV和HSV-2共感染情况.应关注外来务工人员、文化程度低者和使用毒品者.

abstractsObjective To understand the prevalence rates of HIV-syphilis and HIV-herpes simplex virus 2 (HSV-2) co-infections and related factors among men having sex with men (MSM)who had visited the voluntary HIV counseling and testing (VCT) clinics in Shanghai,China.Methods 756 eligible MSM who attended the VCT clinics of Shanghai Municipality and Putuo district during March to August,2015 were recruited to participate in a cross-sectional survey with questionnaire interview and blood testing for HIV,syphilis and HSV-2.Results A total of 732 participants completed a valid questionnaire survey.The prevalence rates were 3.3％ (24/732) for HIV/Syphilis co-infection,1.9％ (14/732) for HIV/HSV-2 co-infection,and 0.7％ (5/732) for HIWSyphilis/HSV-2 co-infection,respectively.HIV prevalence appeared significantly higher among syphilis-infected participants (45.3％,24/53) than those without Syphilis (7.2％,61/679) (x2=63.11,P＜0.001),and was also significantly higher among HSV-2 infected participants (34.1％,14/41) than those without the HSV-2 infection (10.3 ％,71/691) (x2 =21.49,P ＜ 0.001).Results from the Multivariate regression analysis indicated that participants who were migrants (0R=3.50,95％CI:1.01-12.17),having had middle school or lower levels of education (OR=4.46,95％CI:1.54-12.87) or ever used illicit drugs (OR=4.25,95％ CI:1.67-10.82,P=0.002) were under possible risks on HIV and Syphilis co-infection.Those participants who had high middle school or lower levels of education (OR=6.87,95％CI:1.86-25.42;OR=9.82,95％CI:2.25-42.85) were under risk on HIV and HSV-2 co-infection.Conclusion HIV/Syphilis and HIV/HSV-2 co-infection were seen among MSM who attended the VCT clinics in Shanghai that called for special attention,especially on migrants,those with low education or illicit drug users.